An automated miniaturized creatinine sensing system

Son Vu Hoang Lai, David Gaddes, Srinivas A. Tadigadapa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we report on the recently demonstrated, quartz resonator based thermal biosensor configured as a biomedical instrumentation system for continuous monitoring of kidney function based on the measurement of urinary creatinine excretion. The biosensor consists of a reaction chamber which is physically separated but located in close proximity to a micromachined quartz resonator-based temperature sensor. The highly effective coupling of heat from the reaction chamber to the quartz resonator due to close proximity (10-50 microns) and the extremely high absorption coefficient of quartz in the 8-12 μm wavelength range renders this system into a very sensitive thermal sensor design. The non-contact measurement results in no confounding mass loading effects on the quartz resonator and therefore provides clear calorimetric data. The sensor uses creatinine iminohydrolase enzyme immobilized on polystyrene films designed for disposable use. We have successfully integrated the sensor with a programmable miniaturized fluidic system from LabSmith® Inc. to form a miniaturized test system. In this paper we present the latest results on noncontact thermal sensor configuration integrated with miniature automated fluidic system that is capable of continuous monitoring of kidney function based on the measurement of urinary creatinine excretion.

Original languageEnglish (US)
Title of host publicationIEEE SENSORS 2013 - Proceedings
PublisherIEEE Computer Society
ISBN (Print)9781467346405
DOIs
StatePublished - Jan 1 2013
Event12th IEEE SENSORS 2013 Conference - Baltimore, MD, United States
Duration: Nov 4 2013Nov 6 2013

Publication series

NameProceedings of IEEE Sensors

Other

Other12th IEEE SENSORS 2013 Conference
CountryUnited States
CityBaltimore, MD
Period11/4/1311/6/13

Fingerprint

Quartz
Resonators
Sensors
Fluidics
Biosensors
Monitoring
Temperature sensors
Polystyrenes
Enzymes
Wavelength
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Lai, S. V. H., Gaddes, D., & Tadigadapa, S. A. (2013). An automated miniaturized creatinine sensing system. In IEEE SENSORS 2013 - Proceedings [6688285] (Proceedings of IEEE Sensors). IEEE Computer Society. https://doi.org/10.1109/ICSENS.2013.6688285
Lai, Son Vu Hoang ; Gaddes, David ; Tadigadapa, Srinivas A. / An automated miniaturized creatinine sensing system. IEEE SENSORS 2013 - Proceedings. IEEE Computer Society, 2013. (Proceedings of IEEE Sensors).
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Lai, SVH, Gaddes, D & Tadigadapa, SA 2013, An automated miniaturized creatinine sensing system. in IEEE SENSORS 2013 - Proceedings., 6688285, Proceedings of IEEE Sensors, IEEE Computer Society, 12th IEEE SENSORS 2013 Conference, Baltimore, MD, United States, 11/4/13. https://doi.org/10.1109/ICSENS.2013.6688285

An automated miniaturized creatinine sensing system. / Lai, Son Vu Hoang; Gaddes, David; Tadigadapa, Srinivas A.

IEEE SENSORS 2013 - Proceedings. IEEE Computer Society, 2013. 6688285 (Proceedings of IEEE Sensors).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lai SVH, Gaddes D, Tadigadapa SA. An automated miniaturized creatinine sensing system. In IEEE SENSORS 2013 - Proceedings. IEEE Computer Society. 2013. 6688285. (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2013.6688285