An efficacious method for the halogenation of β-dicarbonyl compounds under mildly acidic conditions

Matthew L. Meketa, Yogesh R. Mahajan, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

A variety of 1,3-diketones, β-ketoesters and malonates can be chlorinated in high yields using sodium hypochlorite in a 5:2 mixture of acetone/acetic acid at 0°C for 1 h. Similarly, bromination of these dicarbonyl substrates can be accomplished under the same conditions using sodium hypobromite.

Original languageEnglish (US)
Pages (from-to)4749-4751
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number28
DOIs
StatePublished - Jul 11 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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