An efficient synthesis of geminal di-sulfones

Yimin Zhu, Dale G. Drueckhammer

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A simple and efficient method for the synthesis of gem-disulfones is reported. This method is based on protection of one of the central acidic hydrogens of bis(methylsulfonyl)methane as a thioether followed by formation of the dianion and selective alkylation of the methyl group. Alkylation of one of the methyl groups was demonstrated as well as alkylation of both methyl groups with the same or different alkyl groups. Removal of the thioether moiety furnished the desired substituted disulfones.

Original languageEnglish (US)
Pages (from-to)1377-1379
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number8
DOIs
StatePublished - Feb 18 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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