Maleimycin (1), a minor metabolite of Streptomyces showdoensis possesses antibiotic and antitumor activity but is not available in sufficient quantity from natural sources for complete biological testing. Described is an efficient four step total synthesis of racemic maleimycin from readily available cyclopenten-1,2-dicarboxylic acid, which now makes this metabolite available in quantity.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry