An efficient total synthesis of maleimycin

Pratap Singh, Steven M. Weinreb

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Maleimycin (1), a minor metabolite of Streptomyces showdoensis possesses antibiotic and antitumor activity but is not available in sufficient quantity from natural sources for complete biological testing. Described is an efficient four step total synthesis of racemic maleimycin from readily available cyclopenten-1,2-dicarboxylic acid, which now makes this metabolite available in quantity.

Original languageEnglish (US)
Pages (from-to)2379-2380
Number of pages2
JournalTetrahedron
Volume32
Issue number20
DOIs
StatePublished - Jan 1 1976

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Metabolites
Dicarboxylic Acids
Streptomyces
Anti-Bacterial Agents
Testing
maleimycin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Singh, Pratap ; Weinreb, Steven M. / An efficient total synthesis of maleimycin. In: Tetrahedron. 1976 ; Vol. 32, No. 20. pp. 2379-2380.
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Singh, P & Weinreb, SM 1976, 'An efficient total synthesis of maleimycin', Tetrahedron, vol. 32, no. 20, pp. 2379-2380. https://doi.org/10.1016/0040-4020(76)87018-4

An efficient total synthesis of maleimycin. / Singh, Pratap; Weinreb, Steven M.

In: Tetrahedron, Vol. 32, No. 20, 01.01.1976, p. 2379-2380.

Research output: Contribution to journalArticle

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