An electrothermal bioprocessor with centimeter-scale fluid motion for acute bacterial infection diagnostics in resource-limited settings

Yi Lu, Peter Torab, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study reports a long-range electrothermal bioprocessor for rapid concentration and isolation of bacterial pathogens and on-chip antimicrobial susceptibility testing (AST). Antibiotic resistance is a major global health threat, and rapid microbiological analysis, including pathogen identification and AST, is required for proper management of acute bacterial infections. Using a long-range electrothermal fluid phenomenon we identified recently [1], we design a bioprocessor that concentrates bacterial pathogens for ~3 orders of magnitude (from cm to µm scale) in physiological samples for in situ detection and downstream molecular analysis. By properly controlling the temperature and velocity profiles, we demonstrate the bioprocessor for sample enrichment and on-chip AST in as little as 30 minutes.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1775-1777
Number of pages3
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

Cite this

Lu, Y., Torab, P., & Wong, P. K. (2018). An electrothermal bioprocessor with centimeter-scale fluid motion for acute bacterial infection diagnostics in resource-limited settings. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1775-1777). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society.