An electrothermal micromixer for molecular analysis

Mandy L.Y. Sin, Vinay Gidwani, Vincent Gau, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.

Original languageEnglish (US)
Title of host publication4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Pages827-831
Number of pages5
DOIs
StatePublished - Oct 12 2009
Event4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 - Shenzhen, China
Duration: Jan 5 2009Jan 8 2009

Publication series

Name4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009

Other

Other4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
CountryChina
CityShenzhen
Period1/5/091/8/09

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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