An environmental hazard assessment of low-level dermal exposure to hexavalent chromium in solution among chromium-sensitized volunteers

Joseph F. Fowler, C. Lisa Kauffman, James G. Marks, Deborah M. Proctor, Melissa M. Fredrick, Joanne M. Otani, Brent L. Finley, Dennis J. Paustenbach, James R. Nethercott

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To evaluate the potential for elicitation of allergic contact dermatitis from contact with standing water in the environment, 26 persons known to be allergic to hexavalent chromium [Cr(VI)] were exposed to 25 to 29 mg/L Cr(VI) by immersion of one arm for 30 minutes per day on 3 consecutive days in a potassium dichromate bath. Sixteen of the 26 volunteers demonstrated either no or an equivocal response to the Cr(VI) challenge. Ten of the volunteers developed a few papules or vesicles (1 to approximately 15), mild redness, and pruritus on the Cr(VI)- challenged arm. Histopathological examination of the papules revealed spongiosis and perieccrine and perivascular inflammation. The responses were diagnosed as acute perieccrine reactions. It was concluded that exposure to similar concentrations of Cr(VI) in the environment does not pose an allergic contact dermatitis hazard, even to Cr- sensitized persons.

Original languageEnglish (US)
Pages (from-to)150-160
Number of pages11
JournalJournal of occupational and environmental medicine
Volume41
Issue number3
DOIs
StatePublished - Mar 1999

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'An environmental hazard assessment of low-level dermal exposure to hexavalent chromium in solution among chromium-sensitized volunteers'. Together they form a unique fingerprint.

  • Cite this