An evaluation of the benefits of pulsatile versus nonpulsatile perfusion during cardiopulmonary bypass procedures in pediatric and adult cardiac patients

Bingyang Ji, Akif Undar

Research output: Contribution to journalReview article

102 Citations (Scopus)

Abstract

The controversy over the benefits of pulsatile and nonpulsatile flow during cardiopulmonary bypass procedures continues. The objective of this investigation was to review the literature in order to clarify the truths and dispel the myths regarding the mode of perfusion used during open-heart surgery in pediatric and adult patients. The Google and Medline databases were used to search all of the literature on pulsatile vs. nonpulsatile perfusion published between 1952 and 2006. We found 194 articles related to this topic in the literature. Based on our literature search, we determined that pulsatile flow significantly improved blood flow of the vital organs including brain, heart, liver, and pancreas; reduced the systemic inflammatory response syndrome; and decreased the incidence of postoperative deaths in pediatric and adult patients. We also found evidence that pulsatile flow significantly improved vital organ recovery in several types of animal models when compared with nonpulsatile perfusion. Several investigators have also shown that pulsatile flow generates more hemodynamic energy, which maintains better microcirculation compared with nonpulsatile flow. These results clearly suggest that pulsatile flow is superior to nonpulsatile flow during and after open-heart surgery in pediatric and adult patients.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalASAIO Journal
Volume52
Issue number4
DOIs
StatePublished - Jul 1 2006

Fingerprint

Pulsatile Flow
Pulsatile flow
Pediatrics
Cardiopulmonary Bypass
Perfusion
Surgery
Thoracic Surgery
Microcirculation
Hemodynamics
Systemic Inflammatory Response Syndrome
Liver
Brain
Animals
Blood
Pancreas
Recovery
Animal Models
Research Personnel
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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An evaluation of the benefits of pulsatile versus nonpulsatile perfusion during cardiopulmonary bypass procedures in pediatric and adult cardiac patients. / Ji, Bingyang; Undar, Akif.

In: ASAIO Journal, Vol. 52, No. 4, 01.07.2006, p. 357-361.

Research output: Contribution to journalReview article

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