An evolutionary approach reveals a high protein-coding capacity of the human genome

Anton Nekrutenko, Wen Yu Chung, Wen Hsiung Li

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

We developed a new evolutionary method for identifying exons from genomic sequences and found 19 000 potential coding exons that are absent from all existing annotations of the human genome. Of these, 13 700 satisfied very stringent criteria and can with confidence be considered as novel exons. Evidently, a large number of new human genes can be identified using evolutionary approaches.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
JournalTrends in Genetics
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2003

All Science Journal Classification (ASJC) codes

  • Genetics

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