An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

Max M. Majireck, Jason A. Witek, Steven M. Weinreb

Research output: Contribution to journalArticle

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A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup.

Original languageEnglish (US)
Pages (from-to)3555-3557
Number of pages3
JournalTetrahedron Letters
Issue number27
Publication statusPublished - Jul 7 2010


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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