An exploration of cognitive subgroups in Alzheimers disease

Julie E. Davidson, Michael C. Irizarry, Bethany C. Bray, Sally Wetten, Nicholas Galwey, Rachel Gibson, Michael Borrie, Richard Delisle, Howard H. Feldman, Ging Yuek Hsiung, Luis Fornazzari, Serge Gauthier, Danilo Guzman, Inge Loy-English, Ron Keren, Andrew Kertesz, Peter St George-Hyslop, John Wherrett, Andreas U. Monsch

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Heterogeneity is observed in the patterns of cognition in Alzheimer's disease (AD). Such heterogeneity might suggest the involvement of different etiological pathways or different host responses to pathology. A total of 627 subjects with mild/moderate AD underwent cognitive assessment with the Mini-Mental State Examination (MMSE) and the Dementia Rating Scale-2 (DRS-2). Latent class analysis (LCA) was performed on cognition subscale data to identify and characterize cognitive subgroups. Clinical, demographic, and genetic factors were explored for association with class membership. LCA suggested the existence of four subgroups; one group with mild and another with severe global impairment across the cognitive domains, one group with primary impairments in attention and construction, and another group with primary deficits in memory and orientation. Education, disease duration, age, Apolipoprotein E- ε4 ( APOE ε4) status, gender, presence of grasp reflex, white matter changes, and early or prominent visuospatial impairment were all associated with class membership. Our results support the existence of heterogeneity in patterns of cognitive impairment in AD. Our observation of classes characterized by predominant deficits in attention/construction and memory respectively deserves further exploration as does the association between membership in the attention/ construction class and APOE ε4 negative status.

Original languageEnglish (US)
Pages (from-to)233-243
Number of pages11
JournalJournal of the International Neuropsychological Society
Issue number2
StatePublished - Mar 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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