An IAP-IAP complex inhibits apoptosis

Takehiko Dohi, Kazuya Okada, Fang Xia, Casey E. Wilford, Temesgen Samuel, Kate Welsh, Hiroyouki Marusawa, Hua Zou, Robert Armstrong, Shu Ichi Matsuzawa, Guy S. Salvesen, John C. Reed, Dario C. Altieri

Research output: Contribution to journalArticlepeer-review

331 Scopus citations

Abstract

Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP-/- cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

Original languageEnglish (US)
Pages (from-to)34087-34090
Number of pages4
JournalJournal of Biological Chemistry
Volume279
Issue number33
DOIs
StatePublished - Aug 13 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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