An IAP-IAP complex inhibits apoptosis

Takehiko Dohi; Kazuya Okada; Fang Xia; Casey E. Wilford; Temesgen Samuel; Kate Welsh; Hiroyouki Marusawa; Hua Zou; Robert Armstrong; Shu Ichi Matsuzawa; Guy S. Salvesen; John C. Reed; Dario C. Altieri

doi:10.1074/jbc.C400236200

An IAP-IAP complex inhibits apoptosis

Takehiko Dohi, Kazuya Okada, Fang Xia, Casey E. Wilford, Temesgen Samuel, Kate Welsh, Hiroyouki Marusawa, Hua Zou, Robert Armstrong, Shu Ichi Matsuzawa, Guy S. Salvesen, John C. Reed, Dario C. Altieri

Department of Surgery

Research output: Contribution to journal › Article › peer-review

342 Scopus citations

Abstract

Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP^-/- cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

Original language	English (US)
Pages (from-to)	34087-34090
Number of pages	4
Journal	Journal of Biological Chemistry
Volume	279
Issue number	33
DOIs	https://doi.org/10.1074/jbc.C400236200
State	Published - Aug 13 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "An IAP-IAP complex inhibits apoptosis",

abstract = "Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP-/- cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.",

author = "Takehiko Dohi and Kazuya Okada and Fang Xia and Wilford, {Casey E.} and Temesgen Samuel and Kate Welsh and Hiroyouki Marusawa and Hua Zou and Robert Armstrong and Matsuzawa, {Shu Ichi} and Salvesen, {Guy S.} and Reed, {John C.} and Altieri, {Dario C.}",

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language = "English (US)",

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T1 - An IAP-IAP complex inhibits apoptosis

AU - Dohi, Takehiko

AU - Okada, Kazuya

AU - Xia, Fang

AU - Wilford, Casey E.

AU - Samuel, Temesgen

AU - Welsh, Kate

AU - Marusawa, Hiroyouki

AU - Zou, Hua

AU - Armstrong, Robert

AU - Matsuzawa, Shu Ichi

AU - Salvesen, Guy S.

AU - Reed, John C.

AU - Altieri, Dario C.

PY - 2004/8/13

Y1 - 2004/8/13

N2 - Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP-/- cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

AB - Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP-/- cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

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JO - Journal of Biological Chemistry

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An IAP-IAP complex inhibits apoptosis

Abstract

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