An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure

Ming Da Zhou, Chuan Yang, Zhiwen Liu, Joshua Cysyk, Siyang Zheng

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalBiomedical Microdevices
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2012

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Left ventricular assist devices
Equipment Failure
Heart-Assist Devices
Pressure sensors
Heart Failure
Pressure
Real time control
Micro-Electrical-Mechanical Systems
Ventricular Pressure
Silicon
Diaphragms
Diaphragm
Flow control
Interferometers
Reaction Time
Feedback control
MEMS
Cardiac Arrhythmias
Mirrors
Transplantation

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology

Cite this

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abstract = "Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-P{\'e}rot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.",
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An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure. / Zhou, Ming Da; Yang, Chuan; Liu, Zhiwen; Cysyk, Joshua; Zheng, Siyang.

In: Biomedical Microdevices, Vol. 14, No. 1, 01.02.2012, p. 235-245.

Research output: Contribution to journalArticle

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AB - Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.

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