An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

Bijay Misra, Shantu Amin

Research output: Contribution to journalArticle

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Abstract

Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

Original languageEnglish (US)
Pages (from-to)4478-4480
Number of pages3
JournalJournal of Organic Chemistry
Volume55
Issue number14
DOIs
Publication statusPublished - Jan 1 1990

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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