An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

Bijay Misra, Shantu Amin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

Original languageEnglish (US)
Pages (from-to)4478-4480
Number of pages3
JournalJournal of Organic Chemistry
Volume55
Issue number14
DOIs
StatePublished - Jan 1 1990

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Epoxy Compounds
Metabolism
phenanthrene
benzo(c)phenanthrene

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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title = "An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene",
abstract = "Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).",
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An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene. / Misra, Bijay; Amin, Shantu.

In: Journal of Organic Chemistry, Vol. 55, No. 14, 01.01.1990, p. 4478-4480.

Research output: Contribution to journalArticle

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T1 - An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

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AB - Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

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