An improved synthesis of methyl protodioscin. II. A direct E-ring opening by BF 3-Et 2O/Ac 2O from dioscin ester

Bo Wang, Yang Liu, Xin Liu, Mao Sheng Cheng

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Abstract

A direct E-ring opening of dioscin ester by BF 3-Et 2O/Ac 2O was studied, and methyl protodioscin was synthesized from dioscin ester in three steps with a total yield of 44%. The details of the E-ring opening reaction was discussed, and a prominent stability of C16-OAc was obversed.

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalChemistry Letters
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 25 2012

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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