An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Lisa A. Peterson, Thomas Spratt, Weifeng Shan, Lijuan Wang, Witold Subotkowski, Robert Roth

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume44
Issue number6
DOIs
StatePublished - Jul 9 2001

Fingerprint

Butanones
Tritium
Catalysts
4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

Peterson, Lisa A. ; Spratt, Thomas ; Shan, Weifeng ; Wang, Lijuan ; Subotkowski, Witold ; Roth, Robert. / An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2001 ; Vol. 44, No. 6. pp. 445-450.
@article{7761d73bd4cd4268a0746429216bdd8b,
title = "An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone",
abstract = "The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10{\%} Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.",
author = "Peterson, {Lisa A.} and Thomas Spratt and Weifeng Shan and Lijuan Wang and Witold Subotkowski and Robert Roth",
year = "2001",
month = "7",
day = "9",
doi = "10.1002/jlcr.469",
language = "English (US)",
volume = "44",
pages = "445--450",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone. / Peterson, Lisa A.; Spratt, Thomas; Shan, Weifeng; Wang, Lijuan; Subotkowski, Witold; Roth, Robert.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 44, No. 6, 09.07.2001, p. 445-450.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

AU - Peterson, Lisa A.

AU - Spratt, Thomas

AU - Shan, Weifeng

AU - Wang, Lijuan

AU - Subotkowski, Witold

AU - Roth, Robert

PY - 2001/7/9

Y1 - 2001/7/9

N2 - The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

AB - The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

UR - http://www.scopus.com/inward/record.url?scp=0034951948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034951948&partnerID=8YFLogxK

U2 - 10.1002/jlcr.469

DO - 10.1002/jlcr.469

M3 - Article

AN - SCOPUS:0034951948

VL - 44

SP - 445

EP - 450

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 6

ER -