An increased γδ T cell population in the intestine of thymus-leukemia antigen transgenic mice

Padmanee Sharma, Michael J. Page, Lisa S. Poritz, Walter A. Koltun, Michael J. Chorney

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In an approach to study thymic leukemia antigen's (TL's) function, we have developed transgenic mice that express T18(d) on virtually all somatic cells; in such mice, we initially observed changes in T cells within the thymus and lymph nodes as well as the ability of TL to undergo recognition by splenic T cells. As phase II of our study, we now present the results on the composition of gut T cell populations which may be a better measure of TL's true function. We have demonstrated an increase in the number of γδ+ T cells as well as the increase in γδ+ T cells expressing the Vγ2 chain. These cells appear to be both CD4 and CD8 negative. This suggests that TL may select for a subset of γδ T cells within the gut and bolsters earlier reports implicating an H-2T regional gene product as the major histocompatibility complex ligand for γδ+ T cells.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalCellular Immunology
Volume176
Issue number2
DOIs
StatePublished - Mar 15 1997

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Transgenic Mice
Intestines
T-Lymphocytes
Population
T-Lymphocyte Subsets
Major Histocompatibility Complex
Thymus Gland
thymus-leukemia antigens
Leukemia
Lymph Nodes
Ligands
Genes

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Sharma, Padmanee ; Page, Michael J. ; Poritz, Lisa S. ; Koltun, Walter A. ; Chorney, Michael J. / An increased γδ T cell population in the intestine of thymus-leukemia antigen transgenic mice. In: Cellular Immunology. 1997 ; Vol. 176, No. 2. pp. 153-157.
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An increased γδ T cell population in the intestine of thymus-leukemia antigen transgenic mice. / Sharma, Padmanee; Page, Michael J.; Poritz, Lisa S.; Koltun, Walter A.; Chorney, Michael J.

In: Cellular Immunology, Vol. 176, No. 2, 15.03.1997, p. 153-157.

Research output: Contribution to journalArticle

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