An increased γδ T cell population in the intestine of thymus-leukemia antigen transgenic mice

Padmanee Sharma, Michael J. Page, Lisa S. Poritz, Walter A. Koltun, Michael J. Chorney

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Abstract

In an approach to study thymic leukemia antigen's (TL's) function, we have developed transgenic mice that express T18(d) on virtually all somatic cells; in such mice, we initially observed changes in T cells within the thymus and lymph nodes as well as the ability of TL to undergo recognition by splenic T cells. As phase II of our study, we now present the results on the composition of gut T cell populations which may be a better measure of TL's true function. We have demonstrated an increase in the number of γδ+ T cells as well as the increase in γδ+ T cells expressing the Vγ2 chain. These cells appear to be both CD4 and CD8 negative. This suggests that TL may select for a subset of γδ T cells within the gut and bolsters earlier reports implicating an H-2T regional gene product as the major histocompatibility complex ligand for γδ+ T cells.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalCellular Immunology
Volume176
Issue number2
DOIs
StatePublished - Mar 15 1997

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All Science Journal Classification (ASJC) codes

  • Immunology

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