An Introduction to the Structure and Function of the Catalytic Core Enzyme of Escherichia coli RNA Polymerase

Catherine Sutherland, Katsuhiko S. Murakami

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

RNA polymerase (RNAP) is the essential enzyme responsible for transcribing genetic information stored in DNA to RNA. Understanding the structure and function of RNAP is important for those who study basic principles in gene expression, such as the mechanism of transcription and its regulation, as well as translational sciences such as antibiotic development. With over a half-century of investigations, there is a wealth of information available on the structure and function of Escherichia coli RNAP. This review introduces the structural features of E. coli RNAP, organized by subunit, giving information on the function, location, and conservation of these features to early stage investigators who have just started their research of E. coli RNAP.

Original languageEnglish (US)
JournalEcoSal Plus
Volume8
Issue number1
DOIs
StatePublished - Aug 1 2018

Fingerprint

DNA-Directed RNA Polymerases
Catalytic Domain
Escherichia coli
Enzymes
Research Personnel
RNA
Anti-Bacterial Agents
Gene Expression
DNA
Research

All Science Journal Classification (ASJC) codes

  • Microbiology

Cite this

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An Introduction to the Structure and Function of the Catalytic Core Enzyme of Escherichia coli RNA Polymerase. / Sutherland, Catherine; Murakami, Katsuhiko S.

In: EcoSal Plus, Vol. 8, No. 1, 01.08.2018.

Research output: Contribution to journalReview article

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AB - RNA polymerase (RNAP) is the essential enzyme responsible for transcribing genetic information stored in DNA to RNA. Understanding the structure and function of RNAP is important for those who study basic principles in gene expression, such as the mechanism of transcription and its regulation, as well as translational sciences such as antibiotic development. With over a half-century of investigations, there is a wealth of information available on the structure and function of Escherichia coli RNAP. This review introduces the structural features of E. coli RNAP, organized by subunit, giving information on the function, location, and conservation of these features to early stage investigators who have just started their research of E. coli RNAP.

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