An investigation of the in vivo stability of poly(ether urethaneurea) blood sacs

Limin Wu, David M. Weisberg, James Patrick Runt, George Felder, Alan J. Snyder, Gerson Rosenberg

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In this paper we investigate the biostability of a series of Biolon® blood sacs that were utilized in electric total artificial hearts for time periods of up to 19 weeks. A battery of experimental probes, including scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), were used to characterize the bulk and surface properties of explanted and control blood sacs. Gel permeation chromatography (GPC) experiments showed that generally there was a dramatic increase in average molecular weight at longer implantation times. However, SEM and GPC observations suggest significant deterioration of the flex regions of right blood sacs after 17 weeks of service, XPS experiments indicated appreciable silicon and hydrocarbon concentrations on blood-contacting surfaces both before and after implantation, and we speculate as to their origin.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalJournal of Biomedical Materials Research
Volume44
Issue number4
DOIs
StatePublished - Mar 15 1999

Fingerprint

Ether
Ethers
Blood
Gel permeation chromatography
X ray photoelectron spectroscopy
Artificial heart
Scanning electron microscopy
Silicon
Hyaluronic Acid
Hydrocarbons
Surface properties
Deterioration
Experiments
Molecular weight

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Wu, Limin ; Weisberg, David M. ; Runt, James Patrick ; Felder, George ; Snyder, Alan J. ; Rosenberg, Gerson. / An investigation of the in vivo stability of poly(ether urethaneurea) blood sacs. In: Journal of Biomedical Materials Research. 1999 ; Vol. 44, No. 4. pp. 371-380.
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An investigation of the in vivo stability of poly(ether urethaneurea) blood sacs. / Wu, Limin; Weisberg, David M.; Runt, James Patrick; Felder, George; Snyder, Alan J.; Rosenberg, Gerson.

In: Journal of Biomedical Materials Research, Vol. 44, No. 4, 15.03.1999, p. 371-380.

Research output: Contribution to journalArticle

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AU - Rosenberg, Gerson

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