An opioid growth factor regulates the replication of microorganisms

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

An opioid growth factor (OGF), [Met5]-enkephalin, interacts with the zeta (ζ) opioid receptor to modulate development of eukaryotes. We have found that [Met5]-enkephalin, an endogenous opioid peptide serves to inhibit the growth of S. aureus. This effect on growth involves cell proliferative events and is under tonic control, since potent opioid antagonists accelerate cell replication. Both the OGF and zeta opioid receptor were associated with these microorganisms. Other opioid receptors (μ, δ and κ) were not detected. OGF also controlled the growth of other bacteria: P. aeruginosa and S. marcesans. These results indicate that OGF and its receptor, known to be important in the regulation of mammalian development, also function in the growth of simple unicellular organisms. We suggest that the endogenous opioid system related to growth originated billions of years ago.

Original languageEnglish (US)
Pages (from-to)1179-1187
Number of pages9
JournalLife Sciences
Volume50
Issue number16
DOIs
StatePublished - Jan 1 1992

Fingerprint

Microorganisms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Opioid Receptors
Enkephalins
Growth
Opioid Peptides
Narcotic Antagonists
Cell growth
Bacteria
Eukaryota
zeta receptor

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{a6803aebf048449c8e4b770845f0ac35,
title = "An opioid growth factor regulates the replication of microorganisms",
abstract = "An opioid growth factor (OGF), [Met5]-enkephalin, interacts with the zeta (ζ) opioid receptor to modulate development of eukaryotes. We have found that [Met5]-enkephalin, an endogenous opioid peptide serves to inhibit the growth of S. aureus. This effect on growth involves cell proliferative events and is under tonic control, since potent opioid antagonists accelerate cell replication. Both the OGF and zeta opioid receptor were associated with these microorganisms. Other opioid receptors (μ, δ and κ) were not detected. OGF also controlled the growth of other bacteria: P. aeruginosa and S. marcesans. These results indicate that OGF and its receptor, known to be important in the regulation of mammalian development, also function in the growth of simple unicellular organisms. We suggest that the endogenous opioid system related to growth originated billions of years ago.",
author = "Ian Zagon and Patricia McLaughlin",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0024-3205(92)90461-W",
language = "English (US)",
volume = "50",
pages = "1179--1187",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "16",

}

An opioid growth factor regulates the replication of microorganisms. / Zagon, Ian; McLaughlin, Patricia.

In: Life Sciences, Vol. 50, No. 16, 01.01.1992, p. 1179-1187.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An opioid growth factor regulates the replication of microorganisms

AU - Zagon, Ian

AU - McLaughlin, Patricia

PY - 1992/1/1

Y1 - 1992/1/1

N2 - An opioid growth factor (OGF), [Met5]-enkephalin, interacts with the zeta (ζ) opioid receptor to modulate development of eukaryotes. We have found that [Met5]-enkephalin, an endogenous opioid peptide serves to inhibit the growth of S. aureus. This effect on growth involves cell proliferative events and is under tonic control, since potent opioid antagonists accelerate cell replication. Both the OGF and zeta opioid receptor were associated with these microorganisms. Other opioid receptors (μ, δ and κ) were not detected. OGF also controlled the growth of other bacteria: P. aeruginosa and S. marcesans. These results indicate that OGF and its receptor, known to be important in the regulation of mammalian development, also function in the growth of simple unicellular organisms. We suggest that the endogenous opioid system related to growth originated billions of years ago.

AB - An opioid growth factor (OGF), [Met5]-enkephalin, interacts with the zeta (ζ) opioid receptor to modulate development of eukaryotes. We have found that [Met5]-enkephalin, an endogenous opioid peptide serves to inhibit the growth of S. aureus. This effect on growth involves cell proliferative events and is under tonic control, since potent opioid antagonists accelerate cell replication. Both the OGF and zeta opioid receptor were associated with these microorganisms. Other opioid receptors (μ, δ and κ) were not detected. OGF also controlled the growth of other bacteria: P. aeruginosa and S. marcesans. These results indicate that OGF and its receptor, known to be important in the regulation of mammalian development, also function in the growth of simple unicellular organisms. We suggest that the endogenous opioid system related to growth originated billions of years ago.

UR - http://www.scopus.com/inward/record.url?scp=0026554432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026554432&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(92)90461-W

DO - 10.1016/0024-3205(92)90461-W

M3 - Article

C2 - 1313136

AN - SCOPUS:0026554432

VL - 50

SP - 1179

EP - 1187

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 16

ER -