TY - GEN
T1 - An optimized geometry for simultaneous functional ultrasound and photoacoustic imaging
AU - Liu, Jinyun
AU - Chen, Haoyang
AU - Agrawal, Sumit
AU - Zhang, Nanyin
AU - Gluckman, Bruce
AU - Kothapalli, Sri Rajasekhar
N1 - Funding Information:
This research was funded by NIH-NIBIB R00EB017729-05 (SRK), NIH-NIBIB R21EB030370-01 (SRK), the Penn State Cancer Institute—Highmark seed grant (SRK), College of Engineering multidisciplinary grant, and Grace Woodward grant (SRK).
Publisher Copyright:
© 2022 SPIE.
PY - 2022
Y1 - 2022
N2 - An integrated functional ultrasound (fUS) and photoacoustic (PA) imaging modality is favorable for obtaining multiparametric functional information of deep vasculature. fUS maps blood volume changes of microvasculature using power Doppler frames generated from multiple plane-wave angles with high spatiotemporal resolution, while PA complements vascular oxygen saturation images. In this work, we demonstrated that fUS, ultrasound, and PA imaging can be performed in real-time with a single ultrasound transducer probe. For this, we attached a custom-designed fiber optic illuminator to the fUS probe to optimally deliver light for deep tissue PA imaging. Validation studies on blood flow phantoms and in vivo finger images with a compact imaging head show reduced motion artifacts and ease out the acoustic coupling challenges, making it suitable for multimodal US, fUS and PA imaging of microvasculature.
AB - An integrated functional ultrasound (fUS) and photoacoustic (PA) imaging modality is favorable for obtaining multiparametric functional information of deep vasculature. fUS maps blood volume changes of microvasculature using power Doppler frames generated from multiple plane-wave angles with high spatiotemporal resolution, while PA complements vascular oxygen saturation images. In this work, we demonstrated that fUS, ultrasound, and PA imaging can be performed in real-time with a single ultrasound transducer probe. For this, we attached a custom-designed fiber optic illuminator to the fUS probe to optimally deliver light for deep tissue PA imaging. Validation studies on blood flow phantoms and in vivo finger images with a compact imaging head show reduced motion artifacts and ease out the acoustic coupling challenges, making it suitable for multimodal US, fUS and PA imaging of microvasculature.
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U2 - 10.1117/12.2610443
DO - 10.1117/12.2610443
M3 - Conference contribution
AN - SCOPUS:85131174119
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
T2 - Photons Plus Ultrasound: Imaging and Sensing 2022
Y2 - 20 February 2022 through 24 February 2022
ER -