Abstract

This chapter provides an overview of three crucial aspects of systems biology: constructing biological networks, analyzing and modelling the structure of biological networks and modelling the dynamics of biological networks. We describe the types of intracellular networks most often studied, and the 'omic' information available to synthesize these networks, with a special focus on plant biology. We review the computational methods used to construct or infer (reverse engineer) intracellular networks. We present the graph-theoretical measures most useful for understanding the organization of biological networks, from the single node level to the global properties of the whole network. A representative sample of biological network models is provided, ranging from static models to dynamic models that incorporate how the status of the nodes changes in time. Throughout the chapter we focus on the biological predictions possible by combining experimental, theoretical and computational methods.

Original languageEnglish (US)
Title of host publicationPlant Systems Biology
PublisherBlackwell Publishing Ltd
Pages41-66
Number of pages26
Volume35
ISBN (Electronic)9781444312249
ISBN (Print)9781405162838
DOIs
StatePublished - Aug 18 2009

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Systems Biology
Biological Sciences
Biological Models
plant biology
engineers
dynamic models
prediction
methodology
sampling

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Albert, R. Z., & Assmann, S. M. (2009). An Overview of Systems Biology. In Plant Systems Biology (Vol. 35, pp. 41-66). Blackwell Publishing Ltd. https://doi.org/10.1002/9781444312249.ch2
Albert, Reka Z. ; Assmann, Sarah Mary. / An Overview of Systems Biology. Plant Systems Biology. Vol. 35 Blackwell Publishing Ltd, 2009. pp. 41-66
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Albert, RZ & Assmann, SM 2009, An Overview of Systems Biology. in Plant Systems Biology. vol. 35, Blackwell Publishing Ltd, pp. 41-66. https://doi.org/10.1002/9781444312249.ch2

An Overview of Systems Biology. / Albert, Reka Z.; Assmann, Sarah Mary.

Plant Systems Biology. Vol. 35 Blackwell Publishing Ltd, 2009. p. 41-66.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Albert RZ, Assmann SM. An Overview of Systems Biology. In Plant Systems Biology. Vol. 35. Blackwell Publishing Ltd. 2009. p. 41-66 https://doi.org/10.1002/9781444312249.ch2