An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron

Hao Xi, Meng Chien Lu, Xiaoshi Qian, Qiming Zhang, Sebastian Rupprecht, Qing Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrasensitive magnetoelectric (ME) sensors have been developed using magnetostrictive/piezoelectric laminate heterostructures. This paper discusses a highly interdisciplinary design of a room temperature biomagnetic liver susceptometry system (BLS) based on the ME sensors. The ME-sensor based BLS maintains the ultrahigh sensitivity to detect the weak AC biomagnetic signals and introduces a low equivalent magnetic noise. The results reveal a 'turning point' and successfully indicate the output signals to be linearly responsive to iron concentrations from normal iron level (0.05 mgFe/gliver phantom) to 5 mgFe/gliver phantom iron overload level (100X overdose). Further, the introduction of the water-bag technique shows the promise on the automatic deduction of the background (tissue) signal, enabling an even higher sensitivity and better signal-to-noise (SNR). With these improvements, it becomes feasible to get improved characterization flexibility and the field distribution mapping potential via signal processing from the correlations of multiple sensors in the system. Considering the wide presence of biomagnetic signals in human organs, the potential impact of such biomagnetic devices on medicine and health care could be enormous and far-reaching.

Original languageEnglish (US)
Title of host publicationIEEE Sensors, SENSORS 2016 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479982875
DOIs
StatePublished - Jan 5 2017
Event15th IEEE Sensors Conference, SENSORS 2016 - Orlando, United States
Duration: Oct 30 2016Nov 2 2016

Publication series

NameProceedings of IEEE Sensors
ISSN (Print)1930-0395
ISSN (Electronic)2168-9229

Other

Other15th IEEE Sensors Conference, SENSORS 2016
CountryUnited States
CityOrlando
Period10/30/1611/2/16

Fingerprint

Liver
Iron
Sensors
Bioelectric potentials
Health care
Medicine
Laminates
Heterojunctions
Signal processing
Tissue
Water
Temperature

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Xi, H., Lu, M. C., Qian, X., Zhang, Q., Rupprecht, S., & Yang, Q. (2017). An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron. In IEEE Sensors, SENSORS 2016 - Proceedings [7808778] (Proceedings of IEEE Sensors). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSENS.2016.7808778
Xi, Hao ; Lu, Meng Chien ; Qian, Xiaoshi ; Zhang, Qiming ; Rupprecht, Sebastian ; Yang, Qing. / An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron. IEEE Sensors, SENSORS 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. (Proceedings of IEEE Sensors).
@inproceedings{82343d8f517a4e9c9257748cea6b136d,
title = "An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron",
abstract = "Ultrasensitive magnetoelectric (ME) sensors have been developed using magnetostrictive/piezoelectric laminate heterostructures. This paper discusses a highly interdisciplinary design of a room temperature biomagnetic liver susceptometry system (BLS) based on the ME sensors. The ME-sensor based BLS maintains the ultrahigh sensitivity to detect the weak AC biomagnetic signals and introduces a low equivalent magnetic noise. The results reveal a 'turning point' and successfully indicate the output signals to be linearly responsive to iron concentrations from normal iron level (0.05 mgFe/gliver phantom) to 5 mgFe/gliver phantom iron overload level (100X overdose). Further, the introduction of the water-bag technique shows the promise on the automatic deduction of the background (tissue) signal, enabling an even higher sensitivity and better signal-to-noise (SNR). With these improvements, it becomes feasible to get improved characterization flexibility and the field distribution mapping potential via signal processing from the correlations of multiple sensors in the system. Considering the wide presence of biomagnetic signals in human organs, the potential impact of such biomagnetic devices on medicine and health care could be enormous and far-reaching.",
author = "Hao Xi and Lu, {Meng Chien} and Xiaoshi Qian and Qiming Zhang and Sebastian Rupprecht and Qing Yang",
year = "2017",
month = "1",
day = "5",
doi = "10.1109/ICSENS.2016.7808778",
language = "English (US)",
series = "Proceedings of IEEE Sensors",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "IEEE Sensors, SENSORS 2016 - Proceedings",
address = "United States",

}

Xi, H, Lu, MC, Qian, X, Zhang, Q, Rupprecht, S & Yang, Q 2017, An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron. in IEEE Sensors, SENSORS 2016 - Proceedings., 7808778, Proceedings of IEEE Sensors, Institute of Electrical and Electronics Engineers Inc., 15th IEEE Sensors Conference, SENSORS 2016, Orlando, United States, 10/30/16. https://doi.org/10.1109/ICSENS.2016.7808778

An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron. / Xi, Hao; Lu, Meng Chien; Qian, Xiaoshi; Zhang, Qiming; Rupprecht, Sebastian; Yang, Qing.

IEEE Sensors, SENSORS 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. 7808778 (Proceedings of IEEE Sensors).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron

AU - Xi, Hao

AU - Lu, Meng Chien

AU - Qian, Xiaoshi

AU - Zhang, Qiming

AU - Rupprecht, Sebastian

AU - Yang, Qing

PY - 2017/1/5

Y1 - 2017/1/5

N2 - Ultrasensitive magnetoelectric (ME) sensors have been developed using magnetostrictive/piezoelectric laminate heterostructures. This paper discusses a highly interdisciplinary design of a room temperature biomagnetic liver susceptometry system (BLS) based on the ME sensors. The ME-sensor based BLS maintains the ultrahigh sensitivity to detect the weak AC biomagnetic signals and introduces a low equivalent magnetic noise. The results reveal a 'turning point' and successfully indicate the output signals to be linearly responsive to iron concentrations from normal iron level (0.05 mgFe/gliver phantom) to 5 mgFe/gliver phantom iron overload level (100X overdose). Further, the introduction of the water-bag technique shows the promise on the automatic deduction of the background (tissue) signal, enabling an even higher sensitivity and better signal-to-noise (SNR). With these improvements, it becomes feasible to get improved characterization flexibility and the field distribution mapping potential via signal processing from the correlations of multiple sensors in the system. Considering the wide presence of biomagnetic signals in human organs, the potential impact of such biomagnetic devices on medicine and health care could be enormous and far-reaching.

AB - Ultrasensitive magnetoelectric (ME) sensors have been developed using magnetostrictive/piezoelectric laminate heterostructures. This paper discusses a highly interdisciplinary design of a room temperature biomagnetic liver susceptometry system (BLS) based on the ME sensors. The ME-sensor based BLS maintains the ultrahigh sensitivity to detect the weak AC biomagnetic signals and introduces a low equivalent magnetic noise. The results reveal a 'turning point' and successfully indicate the output signals to be linearly responsive to iron concentrations from normal iron level (0.05 mgFe/gliver phantom) to 5 mgFe/gliver phantom iron overload level (100X overdose). Further, the introduction of the water-bag technique shows the promise on the automatic deduction of the background (tissue) signal, enabling an even higher sensitivity and better signal-to-noise (SNR). With these improvements, it becomes feasible to get improved characterization flexibility and the field distribution mapping potential via signal processing from the correlations of multiple sensors in the system. Considering the wide presence of biomagnetic signals in human organs, the potential impact of such biomagnetic devices on medicine and health care could be enormous and far-reaching.

UR - http://www.scopus.com/inward/record.url?scp=85011002738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011002738&partnerID=8YFLogxK

U2 - 10.1109/ICSENS.2016.7808778

DO - 10.1109/ICSENS.2016.7808778

M3 - Conference contribution

C2 - 29805722

AN - SCOPUS:85011002738

T3 - Proceedings of IEEE Sensors

BT - IEEE Sensors, SENSORS 2016 - Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

ER -

Xi H, Lu MC, Qian X, Zhang Q, Rupprecht S, Yang Q. An ultrasensitive magnetoelectric sensor system for the quantitative detection of liver iron. In IEEE Sensors, SENSORS 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. 7808778. (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2016.7808778