An unbiased estimator of gene diversity in samples containing related individuals

Michael DeGiorgio, Noah A. Rosenberg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Gene diversity is sometimes estimated from samples that contain inbred or related individuals. If inbred or related individuals are included in a sample, then the standard estimator for gene diversity produces a downward bias caused by an inflation of the variance of estimated allele frequencies. We develop an unbiased estimator for gene diversity that relies on kinship coefficients for pairs of individuals with known relationship and that reduces to the standard estimator when all individuals are noninbred and unrelated. Applying our estimator to data simulated based on allele frequencies observed for microsatellite loci in human populations, we find that the new estimator performs favorably compared with the standard estimator in terms of bias and similarly in terms of mean squared error. For human population-genetic data, we find that a close linear relationship previously seen between gene diversity and distance from East Africa is preserved when adjusting for the inclusion of close relatives.

Original languageEnglish (US)
Pages (from-to)501-512
Number of pages12
JournalMolecular biology and evolution
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

gene
Gene Frequency
human population
Genes
gene frequency
allele
genes
sampling
Eastern Africa
kinship
inflation
Economic Inflation
Medical Genetics
Population Genetics
Microsatellite Repeats
population genetics
microsatellite repeats
loci
Population
East Africa

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

DeGiorgio, Michael ; Rosenberg, Noah A. / An unbiased estimator of gene diversity in samples containing related individuals. In: Molecular biology and evolution. 2009 ; Vol. 26, No. 3. pp. 501-512.
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An unbiased estimator of gene diversity in samples containing related individuals. / DeGiorgio, Michael; Rosenberg, Noah A.

In: Molecular biology and evolution, Vol. 26, No. 3, 01.03.2009, p. 501-512.

Research output: Contribution to journalArticle

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