An unexpected presentation: Minimal change disease in an adult with treatment-naïve hepatitis C

Audrey L. Stokes, Tarek Alhamad, Catherine Abendroth, Hosam A. Farag, Navin Verma

Research output: Contribution to journalArticle

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Abstract

Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a middle-aged African-American male who presented with the nephrotic syndrome and acute renal failure and was concomitantly diagnosed with a new hepatitis C infection. He also had a history of urethral strictures with potential reflux nephropathy, which - in combination with his African-American race - also made focal segmental glomerulosclerosis a diagnostic possibility. Full laboratory evaluation did not distinguish the cause of his massive proteinuria; subsequent renal biopsy ultimately revealed minimal change disease. A full course of high-dose steroids eventually reduced his proteinuria, after which his renal failure resolved as well without need for hemodialysis.

Original languageEnglish (US)
Pages (from-to)1801-1804
Number of pages4
JournalInternational Urology and Nephrology
Volume45
Issue number6
DOIs
StatePublished - Dec 1 2013

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All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

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