Analgesic effect of substance P and related hexapeptides

Z. Szreniawski, A. Czlonkowski, Piotr Janicki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Substance P (SP) (90 and 180 nM/kg ip) markedly prolonged the paw-licking latency in mouse hot-plate method, but had little effect on jump-off latency. Analgesic effect of SP was slow in onset and reached its maximum about 60 min after ip administration. SP (180 nM/kg) administered 90 min before experiment increased significantly the stimulation threshold for flinch, squeak and jump response in the mouse flinch-squeak method. Naloxone (1 mg/kg sc) completely blocked the analgesic action of SP. Experiments in vitro showed no binding of SP to the opiate receptor. SP inhibited the locomotor activity; this effect was not antagonized by naloxone. Hexapeptides SP(5-11) (-2) and (pGlu6)SP(6-11) (Z-1) also inhibited the locomotor activity in mice and reduced pain sensitivity. Both hexapeptides showed a moderate binding activity to the opiate receptor in rat striatum.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalPolish Journal of Pharmacology and Pharmacy
Volume31
Issue number6
StatePublished - Jan 1 1979

Fingerprint

Substance P
Analgesics
Opioid Receptors
Locomotion
Naloxone
substance P (6-11)
Pain

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Szreniawski, Z. ; Czlonkowski, A. ; Janicki, Piotr. / Analgesic effect of substance P and related hexapeptides. In: Polish Journal of Pharmacology and Pharmacy. 1979 ; Vol. 31, No. 6. pp. 579-587.
@article{6c1520810f5a435a8c9e576c27b9cabc,
title = "Analgesic effect of substance P and related hexapeptides",
abstract = "Substance P (SP) (90 and 180 nM/kg ip) markedly prolonged the paw-licking latency in mouse hot-plate method, but had little effect on jump-off latency. Analgesic effect of SP was slow in onset and reached its maximum about 60 min after ip administration. SP (180 nM/kg) administered 90 min before experiment increased significantly the stimulation threshold for flinch, squeak and jump response in the mouse flinch-squeak method. Naloxone (1 mg/kg sc) completely blocked the analgesic action of SP. Experiments in vitro showed no binding of SP to the opiate receptor. SP inhibited the locomotor activity; this effect was not antagonized by naloxone. Hexapeptides SP(5-11) (-2) and (pGlu6)SP(6-11) (Z-1) also inhibited the locomotor activity in mice and reduced pain sensitivity. Both hexapeptides showed a moderate binding activity to the opiate receptor in rat striatum.",
author = "Z. Szreniawski and A. Czlonkowski and Piotr Janicki",
year = "1979",
month = "1",
day = "1",
language = "English (US)",
volume = "31",
pages = "579--587",
journal = "Pharmacological Reports",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "6",

}

Analgesic effect of substance P and related hexapeptides. / Szreniawski, Z.; Czlonkowski, A.; Janicki, Piotr.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 31, No. 6, 01.01.1979, p. 579-587.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analgesic effect of substance P and related hexapeptides

AU - Szreniawski, Z.

AU - Czlonkowski, A.

AU - Janicki, Piotr

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Substance P (SP) (90 and 180 nM/kg ip) markedly prolonged the paw-licking latency in mouse hot-plate method, but had little effect on jump-off latency. Analgesic effect of SP was slow in onset and reached its maximum about 60 min after ip administration. SP (180 nM/kg) administered 90 min before experiment increased significantly the stimulation threshold for flinch, squeak and jump response in the mouse flinch-squeak method. Naloxone (1 mg/kg sc) completely blocked the analgesic action of SP. Experiments in vitro showed no binding of SP to the opiate receptor. SP inhibited the locomotor activity; this effect was not antagonized by naloxone. Hexapeptides SP(5-11) (-2) and (pGlu6)SP(6-11) (Z-1) also inhibited the locomotor activity in mice and reduced pain sensitivity. Both hexapeptides showed a moderate binding activity to the opiate receptor in rat striatum.

AB - Substance P (SP) (90 and 180 nM/kg ip) markedly prolonged the paw-licking latency in mouse hot-plate method, but had little effect on jump-off latency. Analgesic effect of SP was slow in onset and reached its maximum about 60 min after ip administration. SP (180 nM/kg) administered 90 min before experiment increased significantly the stimulation threshold for flinch, squeak and jump response in the mouse flinch-squeak method. Naloxone (1 mg/kg sc) completely blocked the analgesic action of SP. Experiments in vitro showed no binding of SP to the opiate receptor. SP inhibited the locomotor activity; this effect was not antagonized by naloxone. Hexapeptides SP(5-11) (-2) and (pGlu6)SP(6-11) (Z-1) also inhibited the locomotor activity in mice and reduced pain sensitivity. Both hexapeptides showed a moderate binding activity to the opiate receptor in rat striatum.

UR - http://www.scopus.com/inward/record.url?scp=0018591081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018591081&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 579

EP - 587

JO - Pharmacological Reports

JF - Pharmacological Reports

SN - 1734-1140

IS - 6

ER -