Analgesic effect of substance P and related hexapeptides

Z. Szreniawski, A. Czlonkowski, P. Janicki

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Substance P (SP) (90 and 180 nM/kg ip) markedly prolonged the paw-licking latency in mouse hot-plate method, but had little effect on jump-off latency. Analgesic effect of SP was slow in onset and reached its maximum about 60 min after ip administration. SP (180 nM/kg) administered 90 min before experiment increased significantly the stimulation threshold for flinch, squeak and jump response in the mouse flinch-squeak method. Naloxone (1 mg/kg sc) completely blocked the analgesic action of SP. Experiments in vitro showed no binding of SP to the opiate receptor. SP inhibited the locomotor activity; this effect was not antagonized by naloxone. Hexapeptides SP(5-11) (-2) and (pGlu6)SP(6-11) (Z-1) also inhibited the locomotor activity in mice and reduced pain sensitivity. Both hexapeptides showed a moderate binding activity to the opiate receptor in rat striatum.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalPolish Journal of Pharmacology and Pharmacy
Volume31
Issue number6
StatePublished - Jan 1 1979

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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