Analgesic efficacy of ketamine and magnesium after laparoscopic sleeve gastrectomy: A randomized, double-blind, placebo-controlled trial

Sanjib Das Adhikary, Venkatesan Thiruvenkatarajan, Andrew McFadden, Wai Man Liu, Berend Mets, Anne Rogers

Research output: Contribution to journalArticlepeer-review

Abstract

Background Ketamine and magnesium are antagonists of the N-methyl-D-aspartate receptor, and are valuable adjuvants for multimodal analgesia and opioid sparing. Data are limited regarding the opioid sparing efficacy of the combined intraoperative application of these agents in laparoscopic bariatric surgery. The objective of this study was to compare the postoperative opioid sparing properties of a single intraoperative dose of ketamine versus a combination of single doses of ketamine and magnesium after laparoscopic gastric sleeve resection in bariatric patients. Methods One hundred and twenty- six patients were randomly assigned to receive single boluses of ketamine alone 0.5 mg kg−1 IV (ketamine group); combined ketamine bolus of 0.5 mg kg−1 IV and magnesium 2 g IV (ketamine and magnesium group); or placebo. Opioid consumption at 24 h (in morphine equivalents); pain at rest; postoperative nausea and vomiting impact score; sedation scores; and trends of transcutaneous carbon-di-oxide values were analysed. Results The median (inter-quartile range [range]) morphine consumption at 24 h were 32 (24–47 [4.8–91]) mg in the ketamine group, 37 (18–53 [1–144]) mg in the ketamine and magnesium group, and 26 (21–36 [5–89]) mg in the control group and were not significantly different between the groups. There were no differences for all other outcomes examined. Conclusion Combined single intraoperative bolus doses of ketamine and magnesium did not result in postoperative opioid sparing after laparoscopic gastric sleeve resection.

Original languageEnglish (US)
Article number110097
JournalJournal of Clinical Anesthesia
Volume68
DOIs
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Analgesic efficacy of ketamine and magnesium after laparoscopic sleeve gastrectomy: A randomized, double-blind, placebo-controlled trial'. Together they form a unique fingerprint.

Cite this