Analysis of aluminum-26 labeled aluminum chlorohydrate

R. Flarend, C. Keim, T. Bin, D. Elmore, S. Hem, M. Ladisch

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A small quantity of aluminum chlorohydrate (ACH), the active ingredient in antiperspirants, was labeled with the radioisotope 26Al. This labeled drug will be used in future studies to measure the absorption of aluminum from antiperspirant use. The purpose of this study was to demonstrate that the technique used to make the 26Al-labeled ACH resulted in a uniformly labeled complex, and therefore any measurement of 26Al would be indicative of total aluminum. The labeled ACH was fractionated using gel filtration chromatography into 72 evenly spaced samples. The fractions were then measured for 26Al and total aluminum content using accelerator mass spectrometry (AMS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Results indicate that the ACH is uniformly labeled. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalJournal of Inorganic Biochemistry
Volume76
Issue number2
DOIs
StatePublished - Aug 30 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry

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