Analysis of candidate genes and hypertension in African American adults

Keith E. Whitfield, Xiaopan Yao, K. B. Boomer, George P. Vogler, Mark D. Hayward, David John Vandenbergh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We investigated the associations between hypertension status and the genotypes of four single nucleotide polymorphism (SNP) sites in four hypertension-related genes (Angiotensinogen [AGT], Angiotensin I Converting Enzyme [ACE], Angiotensinogen II receptor, subtype 1 [AGTR1], and Alpha 1-Antichymotrypsin [ACT or SERPINA3]), in an African American sample. Methods: DNA from 628 participants of the Carolina African American Twin Study of Aging project, a population-based study of African American adult twins, was genotyped using SNPs shown to be associated with hypertension in other studies. Results: The ACE SNP (ACE4 or A-240T) was associated with hypertension (P5.047 in a generalized estimating equations alternating logistics regression model that included age, body mass index, sex, and education. The analysis indicated a protective effect of the TT genotype (odds ratio [OR] 1.59, 95% confidence interval [CI] 1.03-2.48, P=.04) and of the AT genotype (OR 1.91, 95% CI 1.01-3.62, P=.047) compared with the AA genotype. Discussion: These results extend previous findings of associations of various polymorphisms of ACE to hypertension and support the association of hypertension to the A allele of ACE4. The potential for this polymorphism to alter expression by its position in the gene's promoter region suggests that future studies of altered ACE protein activity are warranted.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalEthnicity and Disease
Volume19
Issue number1
StatePublished - Dec 1 2009

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Genetic Association Studies
African Americans
Peptidyl-Dipeptidase A
Hypertension
Genotype
Single Nucleotide Polymorphism
Angiotensinogen
Logistic Models
alpha 1-Antichymotrypsin
Odds Ratio
Confidence Intervals
Twin Studies
Gene Order
Sex Education
Genetic Promoter Regions
Body Mass Index
Alleles
DNA
Population
Genes

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Whitfield, K. E., Yao, X., Boomer, K. B., Vogler, G. P., Hayward, M. D., & Vandenbergh, D. J. (2009). Analysis of candidate genes and hypertension in African American adults. Ethnicity and Disease, 19(1), 18-22.
Whitfield, Keith E. ; Yao, Xiaopan ; Boomer, K. B. ; Vogler, George P. ; Hayward, Mark D. ; Vandenbergh, David John. / Analysis of candidate genes and hypertension in African American adults. In: Ethnicity and Disease. 2009 ; Vol. 19, No. 1. pp. 18-22.
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Whitfield, KE, Yao, X, Boomer, KB, Vogler, GP, Hayward, MD & Vandenbergh, DJ 2009, 'Analysis of candidate genes and hypertension in African American adults', Ethnicity and Disease, vol. 19, no. 1, pp. 18-22.

Analysis of candidate genes and hypertension in African American adults. / Whitfield, Keith E.; Yao, Xiaopan; Boomer, K. B.; Vogler, George P.; Hayward, Mark D.; Vandenbergh, David John.

In: Ethnicity and Disease, Vol. 19, No. 1, 01.12.2009, p. 18-22.

Research output: Contribution to journalArticle

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Whitfield KE, Yao X, Boomer KB, Vogler GP, Hayward MD, Vandenbergh DJ. Analysis of candidate genes and hypertension in African American adults. Ethnicity and Disease. 2009 Dec 1;19(1):18-22.