Analysis of cellular and protein content of broncho alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis

Herbert Reynolds, J. D. Fulmer, J. A. Kazmierowski, W. C. Roberts, M. M. Frank, R. G. Crystal

Research output: Contribution to journalArticle

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Abstract

To evaluate cellular and protein components in the lower respiratory tract of patients with idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP), limited broncho alveolar lavage was done in 58 patients (19 IPF, 7 CHP, and 32 controls). Analysis of the cells and protein in the lavage fluids from patients with IPF revealed an inflammatory and eosinophilic response and a significant elevation of IgG in the lungs. With corticosteroid therapy, inflammation diminished but the eosinophils remained. Lavage fluid from patients with CHP also had eosinophils and elevated levels of IgG. However, in contrast to IPF, lavage fluid from CHP patients contained IgM, fewer inflammatory cells, and a strikingly increased number (38-74%) of lymphocytes. Identification of lavage lymphocytes in CHP showed that T lymphocytes were significantly elevated and B lymphocytes were decreased, compared to peripheral blood. These studies suggest that the lung in IPF and CHP may function as a relatively independent immune organ, and that analysis of cells and proteins in broncho-alveolar lavage fluid may be of diagnostic, therapeutic, and investigative value in evaluating patients with fibrotic lung disease.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalUnknown Journal
Volume59
Issue number1
DOIs
StatePublished - Jan 1 1977

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Extrinsic Allergic Alveolitis
Idiopathic Pulmonary Fibrosis
Bronchoalveolar Lavage Fluid
Therapeutic Irrigation
Proteins
Eosinophils
Immunoglobulin G
Lymphocytes
Lung
Respiratory System
Lung Diseases
Immunoglobulin M
Adrenal Cortex Hormones
B-Lymphocytes
Inflammation
T-Lymphocytes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Reynolds, Herbert ; Fulmer, J. D. ; Kazmierowski, J. A. ; Roberts, W. C. ; Frank, M. M. ; Crystal, R. G. / Analysis of cellular and protein content of broncho alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. In: Unknown Journal. 1977 ; Vol. 59, No. 1. pp. 165-175.
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Analysis of cellular and protein content of broncho alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. / Reynolds, Herbert; Fulmer, J. D.; Kazmierowski, J. A.; Roberts, W. C.; Frank, M. M.; Crystal, R. G.

In: Unknown Journal, Vol. 59, No. 1, 01.01.1977, p. 165-175.

Research output: Contribution to journalArticle

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