Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts

Brett F. Michelotti, Sebastian Brooke, John Mesa, Matthew Z. Wilson, Kurtis Moyer, Donald R. Mackay, Rogerio I. Neves, John Potochny

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase in ADM-specific complications. In this study, we aimed to evaluate clinically significant seroma (CSS) formation - defined by the need for a drainage procedure - to determine if there was a difference in incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This was a retrospective review of consecutive patients who underwent TEBR at a single institution. The total number of reconstructed breasts was separated into the following 4 groups according to the product type: AL, DM, FHD, or no ADM. We identified the total number of CSSs and compared these data between product types. A logistic regression was performed in an attempt to identify independent risk factors associated with seroma formation. In total, we identified 284 consecutive TEBRs. Overall, there were 17 (7.7%) seromas in 220 breast reconstructions in which ADM was used. When comparing the number of CSS between groups - AL (n = 2, 4.0%), DM (n = 6, 5.4%), FHD (n = 9, 14.75%), and no ADM (n = 1, 1.5%) - we found a significant difference in seroma incidence between product types (P = 0.016). Multivariate analysis identified a strong trend toward FHD as an independent predictor of seroma formation (P = 0.061). Our review suggests that there is strong trend in CSS formation with the use of FHD as compared to other product types and reconstructions in which no ADM was used.

Original languageEnglish (US)
Pages (from-to)274-277
Number of pages4
JournalAnnals of plastic surgery
Volume71
Issue number3
DOIs
StatePublished - Sep 1 2013

Fingerprint

Seroma
Acellular Dermis
Mammaplasty
Transplants
Skin
Tissue Expansion Devices
Incidence
Drainage
Breast
Multivariate Analysis
Logistic Models
FlexHD

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Michelotti, Brett F. ; Brooke, Sebastian ; Mesa, John ; Wilson, Matthew Z. ; Moyer, Kurtis ; Mackay, Donald R. ; Neves, Rogerio I. ; Potochny, John. / Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts. In: Annals of plastic surgery. 2013 ; Vol. 71, No. 3. pp. 274-277.
@article{7dd569a9b91f4f4bb224353e2ee1596d,
title = "Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts",
abstract = "With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase in ADM-specific complications. In this study, we aimed to evaluate clinically significant seroma (CSS) formation - defined by the need for a drainage procedure - to determine if there was a difference in incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This was a retrospective review of consecutive patients who underwent TEBR at a single institution. The total number of reconstructed breasts was separated into the following 4 groups according to the product type: AL, DM, FHD, or no ADM. We identified the total number of CSSs and compared these data between product types. A logistic regression was performed in an attempt to identify independent risk factors associated with seroma formation. In total, we identified 284 consecutive TEBRs. Overall, there were 17 (7.7{\%}) seromas in 220 breast reconstructions in which ADM was used. When comparing the number of CSS between groups - AL (n = 2, 4.0{\%}), DM (n = 6, 5.4{\%}), FHD (n = 9, 14.75{\%}), and no ADM (n = 1, 1.5{\%}) - we found a significant difference in seroma incidence between product types (P = 0.016). Multivariate analysis identified a strong trend toward FHD as an independent predictor of seroma formation (P = 0.061). Our review suggests that there is strong trend in CSS formation with the use of FHD as compared to other product types and reconstructions in which no ADM was used.",
author = "Michelotti, {Brett F.} and Sebastian Brooke and John Mesa and Wilson, {Matthew Z.} and Kurtis Moyer and Mackay, {Donald R.} and Neves, {Rogerio I.} and John Potochny",
year = "2013",
month = "9",
day = "1",
doi = "10.1097/SAP.0b013e3182923dc9",
language = "English (US)",
volume = "71",
pages = "274--277",
journal = "Annals of Plastic Surgery",
issn = "0148-7043",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts. / Michelotti, Brett F.; Brooke, Sebastian; Mesa, John; Wilson, Matthew Z.; Moyer, Kurtis; Mackay, Donald R.; Neves, Rogerio I.; Potochny, John.

In: Annals of plastic surgery, Vol. 71, No. 3, 01.09.2013, p. 274-277.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts

AU - Michelotti, Brett F.

AU - Brooke, Sebastian

AU - Mesa, John

AU - Wilson, Matthew Z.

AU - Moyer, Kurtis

AU - Mackay, Donald R.

AU - Neves, Rogerio I.

AU - Potochny, John

PY - 2013/9/1

Y1 - 2013/9/1

N2 - With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase in ADM-specific complications. In this study, we aimed to evaluate clinically significant seroma (CSS) formation - defined by the need for a drainage procedure - to determine if there was a difference in incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This was a retrospective review of consecutive patients who underwent TEBR at a single institution. The total number of reconstructed breasts was separated into the following 4 groups according to the product type: AL, DM, FHD, or no ADM. We identified the total number of CSSs and compared these data between product types. A logistic regression was performed in an attempt to identify independent risk factors associated with seroma formation. In total, we identified 284 consecutive TEBRs. Overall, there were 17 (7.7%) seromas in 220 breast reconstructions in which ADM was used. When comparing the number of CSS between groups - AL (n = 2, 4.0%), DM (n = 6, 5.4%), FHD (n = 9, 14.75%), and no ADM (n = 1, 1.5%) - we found a significant difference in seroma incidence between product types (P = 0.016). Multivariate analysis identified a strong trend toward FHD as an independent predictor of seroma formation (P = 0.061). Our review suggests that there is strong trend in CSS formation with the use of FHD as compared to other product types and reconstructions in which no ADM was used.

AB - With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase in ADM-specific complications. In this study, we aimed to evaluate clinically significant seroma (CSS) formation - defined by the need for a drainage procedure - to determine if there was a difference in incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This was a retrospective review of consecutive patients who underwent TEBR at a single institution. The total number of reconstructed breasts was separated into the following 4 groups according to the product type: AL, DM, FHD, or no ADM. We identified the total number of CSSs and compared these data between product types. A logistic regression was performed in an attempt to identify independent risk factors associated with seroma formation. In total, we identified 284 consecutive TEBRs. Overall, there were 17 (7.7%) seromas in 220 breast reconstructions in which ADM was used. When comparing the number of CSS between groups - AL (n = 2, 4.0%), DM (n = 6, 5.4%), FHD (n = 9, 14.75%), and no ADM (n = 1, 1.5%) - we found a significant difference in seroma incidence between product types (P = 0.016). Multivariate analysis identified a strong trend toward FHD as an independent predictor of seroma formation (P = 0.061). Our review suggests that there is strong trend in CSS formation with the use of FHD as compared to other product types and reconstructions in which no ADM was used.

UR - http://www.scopus.com/inward/record.url?scp=84883305124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883305124&partnerID=8YFLogxK

U2 - 10.1097/SAP.0b013e3182923dc9

DO - 10.1097/SAP.0b013e3182923dc9

M3 - Article

C2 - 23788150

AN - SCOPUS:84883305124

VL - 71

SP - 274

EP - 277

JO - Annals of Plastic Surgery

JF - Annals of Plastic Surgery

SN - 0148-7043

IS - 3

ER -