Analysis of Gene-Gene Interactions

Brian S. Cole, Molly A. Hall, Ryan J. Urbanowicz, Diane Gilbert-Diamond, Jason H. Moore

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.

Original languageEnglish (US)
Pages (from-to)1.14.1-1.14.10
JournalCurrent protocols in human genetics
Volume95
Issue number1
DOIs
StatePublished - Oct 2017

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Analysis of Gene-Gene Interactions'. Together they form a unique fingerprint.

  • Cite this

    Cole, B. S., Hall, M. A., Urbanowicz, R. J., Gilbert-Diamond, D., & Moore, J. H. (2017). Analysis of Gene-Gene Interactions. Current protocols in human genetics, 95(1), 1.14.1-1.14.10. https://doi.org/10.1002/cphg.45