Analysis of Gene-Gene Interactions

Brian S. Cole, Molly A. Hall, Ryan J. Urbanowicz, Diane Gilbert-Diamond, Jason H. Moore

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.

Original languageEnglish (US)
Pages (from-to)1.14.1-1.14.10
JournalCurrent protocols in human genetics
Volume95
Issue number1
DOIs
StatePublished - Oct 2017

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Genes
Disease Susceptibility
Meta-Analysis
Research
Machine Learning

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Cole, B. S., Hall, M. A., Urbanowicz, R. J., Gilbert-Diamond, D., & Moore, J. H. (2017). Analysis of Gene-Gene Interactions. Current protocols in human genetics, 95(1), 1.14.1-1.14.10. https://doi.org/10.1002/cphg.45
Cole, Brian S. ; Hall, Molly A. ; Urbanowicz, Ryan J. ; Gilbert-Diamond, Diane ; Moore, Jason H. / Analysis of Gene-Gene Interactions. In: Current protocols in human genetics. 2017 ; Vol. 95, No. 1. pp. 1.14.1-1.14.10.
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Cole, BS, Hall, MA, Urbanowicz, RJ, Gilbert-Diamond, D & Moore, JH 2017, 'Analysis of Gene-Gene Interactions', Current protocols in human genetics, vol. 95, no. 1, pp. 1.14.1-1.14.10. https://doi.org/10.1002/cphg.45

Analysis of Gene-Gene Interactions. / Cole, Brian S.; Hall, Molly A.; Urbanowicz, Ryan J.; Gilbert-Diamond, Diane; Moore, Jason H.

In: Current protocols in human genetics, Vol. 95, No. 1, 10.2017, p. 1.14.1-1.14.10.

Research output: Contribution to journalReview article

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AU - Moore, Jason H.

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Cole BS, Hall MA, Urbanowicz RJ, Gilbert-Diamond D, Moore JH. Analysis of Gene-Gene Interactions. Current protocols in human genetics. 2017 Oct;95(1):1.14.1-1.14.10. https://doi.org/10.1002/cphg.45