Analysis of multiple-dose bioequivalence studies

Vernon M. Chinchilli, James D. Esinhari, William H. Barâ

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In multiple-dose bioequivalence studies, it is possible at steady state to take repeated measurements of pharmacokinetic variables, such as area under the curve (AUC) and the maximum concentration (CMAX) of the blood concentration-time profile, within each period of a crossover design. We develop a bivariate random effects model for such a situation in a 2 x 2 crossover design using the natural.

Original languageEnglish (US)
Pages (from-to)423-435
Number of pages13
JournalJournal of Biopharmaceutical Statistics
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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