Analiza polimorfizma C609T gena za NQO1 u bolesnika s hematološkim malignim bolestima u južnoj hrvatskoj

Translated title of the contribution: Analysis of the C609T polymorphism of NQO1 gene in south croatian patients with hematological malignancies

Bernarda Lozić, Dragan Primorac, Robert Glavinić, Radenka Kuzmanić Šamija, Tatijana Zemunik

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of hematopoietic malignancies.We analyzed C609T polymorphism in NQO1 gene in the group of 82 patients (56 adult and 26 children) with different type of hematopoietic malignancies and 99 healthy participants (61 adult and 38 children) using PCR and the RFLP method. We confirmed that the polymorphism C609T in NQO1 gene was more frequent in the adult patients' group with myeloid disorders, (p=0.0267) compared with adult controls.We could not confirm the association C609T polymorphism with recurrent chromosome translocations (clonal karyotype changes) neither in the adult nor in pediatric group of patients.

Translated title of the contributionAnalysis of the C609T polymorphism of NQO1 gene in south croatian patients with hematological malignancies
Original languageUndefined/Unknown
Pages (from-to)385-388
Number of pages4
JournalCollegium Antropologicum
Volume35
Issue number2
StatePublished - Jun 1 2011

All Science Journal Classification (ASJC) codes

  • Anthropology
  • Arts and Humanities (miscellaneous)

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    Lozić, B., Primorac, D., Glavinić, R., Šamija, R. K., & Zemunik, T. (2011). Analiza polimorfizma C609T gena za NQO1 u bolesnika s hematološkim malignim bolestima u južnoj hrvatskoj. Collegium Antropologicum, 35(2), 385-388.