Abstract
Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1830-1838 |
| Number of pages | 9 |
| Journal | Biology of Blood and Marrow Transplantation |
| Volume | 21 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2015 |
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All Science Journal Classification (ASJC) codes
- Hematology
- Transplantation
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Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes : Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers. / Shaw, Bronwen E.; Logan, Brent R.; Kiefer, Deidre M.; Chitphakdithai, Pintip; Pedersen, Tanya L.; Abdel-Azim, Hisham; Abidi, Muneer H.; Akpek, Gorgun; Diaz, Miguel A.; Artz, Andrew S.; Dandoy, Christopher; Gajewski, James L.; Hematti, Peiman; Kamble, Rammurti T.; Kasow, Kimberley A.; Lazarus, Hillard M.; Liesveld, Jane L.; Majhail, Navneet S.; O'Donnell, Paul V.; Olsson, Richard F.; Savani, Bipin N.; Schears, Raquel M.; Stroncek, David F.; Switzer, Galen E.; Williams, Eric P.; Wingard, John R.; Wirk, Baldeep M.; Confer, Dennis L.; Pulsipher, Michael A.
In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 10, 01.10.2015, p. 1830-1838.Research output: Contribution to journal › Article
TY - JOUR
T1 - Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes
T2 - Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers
AU - Shaw, Bronwen E.
AU - Logan, Brent R.
AU - Kiefer, Deidre M.
AU - Chitphakdithai, Pintip
AU - Pedersen, Tanya L.
AU - Abdel-Azim, Hisham
AU - Abidi, Muneer H.
AU - Akpek, Gorgun
AU - Diaz, Miguel A.
AU - Artz, Andrew S.
AU - Dandoy, Christopher
AU - Gajewski, James L.
AU - Hematti, Peiman
AU - Kamble, Rammurti T.
AU - Kasow, Kimberley A.
AU - Lazarus, Hillard M.
AU - Liesveld, Jane L.
AU - Majhail, Navneet S.
AU - O'Donnell, Paul V.
AU - Olsson, Richard F.
AU - Savani, Bipin N.
AU - Schears, Raquel M.
AU - Stroncek, David F.
AU - Switzer, Galen E.
AU - Williams, Eric P.
AU - Wingard, John R.
AU - Wirk, Baldeep M.
AU - Confer, Dennis L.
AU - Pulsipher, Michael A.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.
AB - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.
UR - http://www.scopus.com/inward/record.url?scp=84941317226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941317226&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2015.06.013
DO - 10.1016/j.bbmt.2015.06.013
M3 - Article
C2 - 26116089
AN - SCOPUS:84941317226
VL - 21
SP - 1830
EP - 1838
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 10
ER -