Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers

Bronwen E. Shaw, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Tanya L. Pedersen, Hisham Abdel-Azim, Muneer H. Abidi, Gorgun Akpek, Miguel A. Diaz, Andrew S. Artz, Christopher Dandoy, James L. Gajewski, Peiman Hematti, Rammurti T. Kamble, Kimberley A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Navneet S. Majhail, Paul V. O'Donnell, Richard F. OlssonBipin N. Savani, Raquel M. Schears, David F. Stroncek, Galen E. Switzer, Eric P. Williams, John R. Wingard, Baldeep M. Wirk, Dennis L. Confer, Michael A. Pulsipher

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

Original languageEnglish (US)
Pages (from-to)1830-1838
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2015

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Social Class
Bone Marrow
Tissue Donors
Pain
Unrelated Donors
Registries
Body Mass Index
Peripheral Blood Stem Cells

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Shaw, Bronwen E. ; Logan, Brent R. ; Kiefer, Deidre M. ; Chitphakdithai, Pintip ; Pedersen, Tanya L. ; Abdel-Azim, Hisham ; Abidi, Muneer H. ; Akpek, Gorgun ; Diaz, Miguel A. ; Artz, Andrew S. ; Dandoy, Christopher ; Gajewski, James L. ; Hematti, Peiman ; Kamble, Rammurti T. ; Kasow, Kimberley A. ; Lazarus, Hillard M. ; Liesveld, Jane L. ; Majhail, Navneet S. ; O'Donnell, Paul V. ; Olsson, Richard F. ; Savani, Bipin N. ; Schears, Raquel M. ; Stroncek, David F. ; Switzer, Galen E. ; Williams, Eric P. ; Wingard, John R. ; Wirk, Baldeep M. ; Confer, Dennis L. ; Pulsipher, Michael A. / Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes : Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers. In: Biology of Blood and Marrow Transplantation. 2015 ; Vol. 21, No. 10. pp. 1830-1838.
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abstract = "Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.",
author = "Shaw, {Bronwen E.} and Logan, {Brent R.} and Kiefer, {Deidre M.} and Pintip Chitphakdithai and Pedersen, {Tanya L.} and Hisham Abdel-Azim and Abidi, {Muneer H.} and Gorgun Akpek and Diaz, {Miguel A.} and Artz, {Andrew S.} and Christopher Dandoy and Gajewski, {James L.} and Peiman Hematti and Kamble, {Rammurti T.} and Kasow, {Kimberley A.} and Lazarus, {Hillard M.} and Liesveld, {Jane L.} and Majhail, {Navneet S.} and O'Donnell, {Paul V.} and Olsson, {Richard F.} and Savani, {Bipin N.} and Schears, {Raquel M.} and Stroncek, {David F.} and Switzer, {Galen E.} and Williams, {Eric P.} and Wingard, {John R.} and Wirk, {Baldeep M.} and Confer, {Dennis L.} and Pulsipher, {Michael A.}",
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Shaw, BE, Logan, BR, Kiefer, DM, Chitphakdithai, P, Pedersen, TL, Abdel-Azim, H, Abidi, MH, Akpek, G, Diaz, MA, Artz, AS, Dandoy, C, Gajewski, JL, Hematti, P, Kamble, RT, Kasow, KA, Lazarus, HM, Liesveld, JL, Majhail, NS, O'Donnell, PV, Olsson, RF, Savani, BN, Schears, RM, Stroncek, DF, Switzer, GE, Williams, EP, Wingard, JR, Wirk, BM, Confer, DL & Pulsipher, MA 2015, 'Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers', Biology of Blood and Marrow Transplantation, vol. 21, no. 10, pp. 1830-1838. https://doi.org/10.1016/j.bbmt.2015.06.013

Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes : Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers. / Shaw, Bronwen E.; Logan, Brent R.; Kiefer, Deidre M.; Chitphakdithai, Pintip; Pedersen, Tanya L.; Abdel-Azim, Hisham; Abidi, Muneer H.; Akpek, Gorgun; Diaz, Miguel A.; Artz, Andrew S.; Dandoy, Christopher; Gajewski, James L.; Hematti, Peiman; Kamble, Rammurti T.; Kasow, Kimberley A.; Lazarus, Hillard M.; Liesveld, Jane L.; Majhail, Navneet S.; O'Donnell, Paul V.; Olsson, Richard F.; Savani, Bipin N.; Schears, Raquel M.; Stroncek, David F.; Switzer, Galen E.; Williams, Eric P.; Wingard, John R.; Wirk, Baldeep M.; Confer, Dennis L.; Pulsipher, Michael A.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 10, 01.10.2015, p. 1830-1838.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes

T2 - Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers

AU - Shaw, Bronwen E.

AU - Logan, Brent R.

AU - Kiefer, Deidre M.

AU - Chitphakdithai, Pintip

AU - Pedersen, Tanya L.

AU - Abdel-Azim, Hisham

AU - Abidi, Muneer H.

AU - Akpek, Gorgun

AU - Diaz, Miguel A.

AU - Artz, Andrew S.

AU - Dandoy, Christopher

AU - Gajewski, James L.

AU - Hematti, Peiman

AU - Kamble, Rammurti T.

AU - Kasow, Kimberley A.

AU - Lazarus, Hillard M.

AU - Liesveld, Jane L.

AU - Majhail, Navneet S.

AU - O'Donnell, Paul V.

AU - Olsson, Richard F.

AU - Savani, Bipin N.

AU - Schears, Raquel M.

AU - Stroncek, David F.

AU - Switzer, Galen E.

AU - Williams, Eric P.

AU - Wingard, John R.

AU - Wirk, Baldeep M.

AU - Confer, Dennis L.

AU - Pulsipher, Michael A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

AB - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

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