Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors

Eric T. Harvill, Manuel Osorio, Crystal L. Loving, Gloria M. Lee, Vanessa K. Kelly, Tod J. Merkel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mechanisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced immunity have been less well studied and defined. We used a combination of complement depletion along with immunodeficient mice and adoptive transfer approaches to determine the mechanisms of infection-induced protective immunity to B. anthracis. B- or T-cell-deficient mice lacked the complete anamnestic protection observed in immunocompetent mice. In addition, T-cell-deficient mice generated poor antibody titers but were protected by the adoptive transfer of serum from B. anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors. Together, these results indicate that antibody-mediated neutralization provides significant protection in B. anthracis infection-induced immunity.

Original languageEnglish (US)
Pages (from-to)2177-2182
Number of pages6
JournalInfection and Immunity
Volume76
Issue number5
DOIs
StatePublished - May 2008

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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