Anaplastic renal carcinoma expressing SV40 T antigen in a female TRAMP mouse

Erin M. Goodwin, Qing Zhong, Catherine S. Abendroth, Lindsay K. Ward-Kavanagh, Todd D. Schell, Timothy K. Cooper

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Abstract

An 8-mo-old female transgenic adenocarcinoma of the mouse prostate (C57BL/6-Tg(TRAMP)8247Ng/J) mouse presented with abdominal distention, lethargy, and serosanguineous vaginal discharge. A large primary renal tumor with metastases to lung and liver was present at necropsy. The tumor was composed of poorly differentiated and crowded epithelial cells forming ducts, acini, and cribriform patterns, with comedonecrosis and frequent bizarre mitoses. Immunohistochemistry revealed that neoplastic cells expressed nuclear SV40 T antigen, confirming aberrant expression of the transgene. In addition, cells were positive for pancytokeratin and negative for synaptophysin and estrogen and progesterone receptors. This report details the first transgene-induced tumor in a female TRAMP mouse.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalComparative Medicine
Volume63
Issue number4
Publication statusPublished - Aug 1 2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Goodwin, E. M., Zhong, Q., Abendroth, C. S., Ward-Kavanagh, L. K., Schell, T. D., & Cooper, T. K. (2013). Anaplastic renal carcinoma expressing SV40 T antigen in a female TRAMP mouse. Comparative Medicine, 63(4), 338-341.