Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

Jordan N. Norwood, Qingguang Zhang, David Card, Amanda Craine, Timothy M. Ryan, Patrick J. Drew

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, we characterized the anatomy and physiological function of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in intracranial pressure (ICP), consistent with an alteration in the pattern of CSF drainage or production. Our results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases.

Original languageEnglish (US)
Article numbere44278
JournaleLife
Volume8
DOIs
StatePublished - May 2019

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Ethmoid Bone
Cerebrospinal fluid
Cerebrospinal Fluid
Olfactory Nerve
Brain
Olfactory Receptor Neurons
Intracranial Hypertension
Nasal Mucosa
Air Pollution
Ablation
Air pollution
Anatomy
Drainage
Neurons
Flow of fluids

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, we characterized the anatomy and physiological function of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in intracranial pressure (ICP), consistent with an alteration in the pattern of CSF drainage or production. Our results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases.",
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Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate. / Norwood, Jordan N.; Zhang, Qingguang; Card, David; Craine, Amanda; Ryan, Timothy M.; Drew, Patrick J.

In: eLife, Vol. 8, e44278, 05.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

AU - Norwood, Jordan N.

AU - Zhang, Qingguang

AU - Card, David

AU - Craine, Amanda

AU - Ryan, Timothy M.

AU - Drew, Patrick J.

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