Ancient origin of the new developmental superfamily DANGER

Nikolas Nikolaidis, Dimitra Chalkia, D. Neil Watkins, Roxanne K. Barrow, Solomon H. Snyder, Damian B. Van Rossum, Randen L. Patterson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Developmental proteins play a pivotal role in the origin of animal complexity and diversity. We report here the identification of a highly divergent developmental protein superfamily (DANGER), which originated before the emergence of animals (∼850 million years ago) and experienced major expansion-contraction events during metazoan evolution. Sequence analysis demonstrates that DANGER proteins diverged via multiple mechanisms, including amino acid substitution, intron gain and/or loss, and recombination. Divergence for DANGER proteins is substantially greater than for the prototypic member of the superfamily (Mab-21 family) and other developmental protein families (e.g., WNT proteins). DANGER proteins are widely expressed and display species-dependent tissue expression patterns, with many members having roles in development. DANGER1A, which regulates the inositol trisphosphate receptor, promotes the differentiation and outgrowth of neuronal processes. Regulation of development may be a universal function of DANGER family members. This family provides a model system to investigate how rapid protein divergence contributes to morphological complexity.

Original languageEnglish (US)
Article numbere204
JournalPloS one
Volume2
Issue number2
DOIs
StatePublished - Feb 14 2007

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Proteins
proteins
Animals
amino acid substitution
Inositol
Amino Acid Substitution
Introns
Genetic Recombination
Sequence Analysis
introns
animals
Substitution reactions
sequence analysis
Tissue
Amino Acids
receptors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nikolaidis, N., Chalkia, D., Watkins, D. N., Barrow, R. K., Snyder, S. H., Van Rossum, D. B., & Patterson, R. L. (2007). Ancient origin of the new developmental superfamily DANGER. PloS one, 2(2), [e204]. https://doi.org/10.1371/journal.pone.0000204
Nikolaidis, Nikolas ; Chalkia, Dimitra ; Watkins, D. Neil ; Barrow, Roxanne K. ; Snyder, Solomon H. ; Van Rossum, Damian B. ; Patterson, Randen L. / Ancient origin of the new developmental superfamily DANGER. In: PloS one. 2007 ; Vol. 2, No. 2.
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Nikolaidis, N, Chalkia, D, Watkins, DN, Barrow, RK, Snyder, SH, Van Rossum, DB & Patterson, RL 2007, 'Ancient origin of the new developmental superfamily DANGER', PloS one, vol. 2, no. 2, e204. https://doi.org/10.1371/journal.pone.0000204

Ancient origin of the new developmental superfamily DANGER. / Nikolaidis, Nikolas; Chalkia, Dimitra; Watkins, D. Neil; Barrow, Roxanne K.; Snyder, Solomon H.; Van Rossum, Damian B.; Patterson, Randen L.

In: PloS one, Vol. 2, No. 2, e204, 14.02.2007.

Research output: Contribution to journalArticle

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Nikolaidis N, Chalkia D, Watkins DN, Barrow RK, Snyder SH, Van Rossum DB et al. Ancient origin of the new developmental superfamily DANGER. PloS one. 2007 Feb 14;2(2). e204. https://doi.org/10.1371/journal.pone.0000204