Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract

G. J. Wirth, A. Haitel, M. Moschini, F. Soria, T. Klatte, M. R. Hassler, K. Bensalah, A. Briganti, J. A. Karam, Y. Lotan, V. Margulis, Jay Raman, M. Remzi, N. Rioux-Leclercq, B. D. Robinson, M. Rouprêt, C. G. Wood, S. F. Shariat

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

Original languageEnglish (US)
Pages (from-to)943-949
Number of pages7
JournalWorld Journal of Urology
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Androgen Receptors
Urinary Tract
Carcinoma
Neoplasms
Survival
Ureter
Recurrence
Necrosis
Steroids
Hormones

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Wirth, G. J. ; Haitel, A. ; Moschini, M. ; Soria, F. ; Klatte, T. ; Hassler, M. R. ; Bensalah, K. ; Briganti, A. ; Karam, J. A. ; Lotan, Y. ; Margulis, V. ; Raman, Jay ; Remzi, M. ; Rioux-Leclercq, N. ; Robinson, B. D. ; Rouprêt, M. ; Wood, C. G. ; Shariat, S. F. / Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract. In: World Journal of Urology. 2017 ; Vol. 35, No. 6. pp. 943-949.
@article{12e05c5897b043bd916461342a501a3e,
title = "Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract",
abstract = "Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 {\%} of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 {\%} of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.",
author = "Wirth, {G. J.} and A. Haitel and M. Moschini and F. Soria and T. Klatte and Hassler, {M. R.} and K. Bensalah and A. Briganti and Karam, {J. A.} and Y. Lotan and V. Margulis and Jay Raman and M. Remzi and N. Rioux-Leclercq and Robinson, {B. D.} and M. Roupr{\^e}t and Wood, {C. G.} and Shariat, {S. F.}",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s00345-016-1946-8",
language = "English (US)",
volume = "35",
pages = "943--949",
journal = "World Journal of Urology",
issn = "0724-4983",
publisher = "Springer Verlag",
number = "6",

}

Wirth, GJ, Haitel, A, Moschini, M, Soria, F, Klatte, T, Hassler, MR, Bensalah, K, Briganti, A, Karam, JA, Lotan, Y, Margulis, V, Raman, J, Remzi, M, Rioux-Leclercq, N, Robinson, BD, Rouprêt, M, Wood, CG & Shariat, SF 2017, 'Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract', World Journal of Urology, vol. 35, no. 6, pp. 943-949. https://doi.org/10.1007/s00345-016-1946-8

Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract. / Wirth, G. J.; Haitel, A.; Moschini, M.; Soria, F.; Klatte, T.; Hassler, M. R.; Bensalah, K.; Briganti, A.; Karam, J. A.; Lotan, Y.; Margulis, V.; Raman, Jay; Remzi, M.; Rioux-Leclercq, N.; Robinson, B. D.; Rouprêt, M.; Wood, C. G.; Shariat, S. F.

In: World Journal of Urology, Vol. 35, No. 6, 01.06.2017, p. 943-949.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract

AU - Wirth, G. J.

AU - Haitel, A.

AU - Moschini, M.

AU - Soria, F.

AU - Klatte, T.

AU - Hassler, M. R.

AU - Bensalah, K.

AU - Briganti, A.

AU - Karam, J. A.

AU - Lotan, Y.

AU - Margulis, V.

AU - Raman, Jay

AU - Remzi, M.

AU - Rioux-Leclercq, N.

AU - Robinson, B. D.

AU - Rouprêt, M.

AU - Wood, C. G.

AU - Shariat, S. F.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

AB - Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

UR - http://www.scopus.com/inward/record.url?scp=84991111356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991111356&partnerID=8YFLogxK

U2 - 10.1007/s00345-016-1946-8

DO - 10.1007/s00345-016-1946-8

M3 - Article

VL - 35

SP - 943

EP - 949

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 6

ER -