Androgens accelerate thymocyte apoptosis

Nancy J. Olsen, Susan M. Viselli, Jin Fan, William J. Kovacs

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Mechanisms of androgen-induced thymic involution are largely undefined. We have found that significant decreases in thymic size occur 2-4 h after a dose of testosterone is administered to castrated male mice. This rapid rate of change suggests a role for androgen-induced apoptosis in modulating the size and composition of the thymus. Using thymic organ cultures to define these effects of androgens, we found that dihydrotestosterone treatment of thymus tissues from femmes or from castrated males results in enhancement of thymocyte apoptosis. Intact (androgen-replete) or testicular feminization, Tfm/Y (androgen-resistant) mice failed to show apoptotic change with androgen treatment, although the apoptotic response to glucocorticoids was present, suggesting a requirement for a functional androgen receptor. Acceleration of thymocyte apoptosis by androgens may mediate processes of thymocyte selection, with the potential to impart gender-specific characteristics on the peripheral T cell repertoire.

Original languageEnglish (US)
Pages (from-to)748-752
Number of pages5
JournalEndocrinology
Volume139
Issue number2
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Endocrinology

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