Angiogenesis and survival in patients with myelodysplastic syndrome

Aleksandar Savic, Vesna Cemerikic-Martinovic, Sinisa Dovat, Nebojsa Rajic, Ivana Urosevic, Borivoj Sekulic, Vanja Kvrgic, Stevan Popovic

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.

Original languageEnglish (US)
Pages (from-to)681-690
Number of pages10
JournalPathology and Oncology Research
Volume18
Issue number3
DOIs
StatePublished - Jul 1 2012

Fingerprint

Myelodysplastic Syndromes
Microvessels
Vascular Endothelial Growth Factor A
Survival
Acute Myeloid Leukemia
Cytogenetics
Platelet Count
Paraffin
Multivariate Analysis
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Savic, A., Cemerikic-Martinovic, V., Dovat, S., Rajic, N., Urosevic, I., Sekulic, B., ... Popovic, S. (2012). Angiogenesis and survival in patients with myelodysplastic syndrome. Pathology and Oncology Research, 18(3), 681-690. https://doi.org/10.1007/s12253-012-9495-y
Savic, Aleksandar ; Cemerikic-Martinovic, Vesna ; Dovat, Sinisa ; Rajic, Nebojsa ; Urosevic, Ivana ; Sekulic, Borivoj ; Kvrgic, Vanja ; Popovic, Stevan. / Angiogenesis and survival in patients with myelodysplastic syndrome. In: Pathology and Oncology Research. 2012 ; Vol. 18, No. 3. pp. 681-690.
@article{bd2423b0493e4a8eafa1dd25f5819c78,
title = "Angiogenesis and survival in patients with myelodysplastic syndrome",
abstract = "Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.",
author = "Aleksandar Savic and Vesna Cemerikic-Martinovic and Sinisa Dovat and Nebojsa Rajic and Ivana Urosevic and Borivoj Sekulic and Vanja Kvrgic and Stevan Popovic",
year = "2012",
month = "7",
day = "1",
doi = "10.1007/s12253-012-9495-y",
language = "English (US)",
volume = "18",
pages = "681--690",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "3",

}

Savic, A, Cemerikic-Martinovic, V, Dovat, S, Rajic, N, Urosevic, I, Sekulic, B, Kvrgic, V & Popovic, S 2012, 'Angiogenesis and survival in patients with myelodysplastic syndrome', Pathology and Oncology Research, vol. 18, no. 3, pp. 681-690. https://doi.org/10.1007/s12253-012-9495-y

Angiogenesis and survival in patients with myelodysplastic syndrome. / Savic, Aleksandar; Cemerikic-Martinovic, Vesna; Dovat, Sinisa; Rajic, Nebojsa; Urosevic, Ivana; Sekulic, Borivoj; Kvrgic, Vanja; Popovic, Stevan.

In: Pathology and Oncology Research, Vol. 18, No. 3, 01.07.2012, p. 681-690.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Angiogenesis and survival in patients with myelodysplastic syndrome

AU - Savic, Aleksandar

AU - Cemerikic-Martinovic, Vesna

AU - Dovat, Sinisa

AU - Rajic, Nebojsa

AU - Urosevic, Ivana

AU - Sekulic, Borivoj

AU - Kvrgic, Vanja

AU - Popovic, Stevan

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.

AB - Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.

UR - http://www.scopus.com/inward/record.url?scp=84863975376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863975376&partnerID=8YFLogxK

U2 - 10.1007/s12253-012-9495-y

DO - 10.1007/s12253-012-9495-y

M3 - Article

C2 - 22270865

AN - SCOPUS:84863975376

VL - 18

SP - 681

EP - 690

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 3

ER -

Savic A, Cemerikic-Martinovic V, Dovat S, Rajic N, Urosevic I, Sekulic B et al. Angiogenesis and survival in patients with myelodysplastic syndrome. Pathology and Oncology Research. 2012 Jul 1;18(3):681-690. https://doi.org/10.1007/s12253-012-9495-y