Angiotensin-converting enzyme inhibition reverses luteal phase steroid production in oocyte donors

R. S. Morris, R. J. Paulson, S. R. Lindhelm, R. S. Legro, R. A. Lobo, M. V. Sauer

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Abstract

Objective: To determine whether angiotensin-converting enzyme (ACE) inhibition would affect ovarian steroid synthesis in the oocyte donors undergoing controlled ovarian hyperstimulalion (COH). Setting: The IVF program of the University of Southern California. Design: Prospective matched clinical trial. Patients: Twelve oocyte donors were studied in 28 hyperstimulation cycles. Interventions: Donors underwent a standard COH protocol. Follicle aspiration was performed 34 hours after administration of hCG. After the procedure, seven donors were administered the ACE inhibitor, captopril, 6.25 mg orally twice daily for 4 days. The remaining patients served as Main Outcome Measures: Serum E2, P, plasma prorenin, active renin, and angiotensin II (Ang II). Results: Angiotensin II increased after aspiration in both groups hut was significantly lower in those receiving captopril. Peak P in the captopril group was significantly lower than controls (81.8 ± 27.8 versus 208.5 ± 23.9 ng/mL [conversion factor to SI unit, 3.180]). Peak E2 was significantly higher (2,222.4 ± 875.3 versus 425.6 ± 490.4 pg/mL [conversion factor to SI unit, 3.671]). Active renin and Ang II correlated with P. Conclusions: In stimulated cycles, inhibition of Ang II production appears to raise serum E2 and lower P levels. Angiotensin II, therefore, may have a role in the regulation of ovarian steroid synthesis.

Original languageEnglish (US)
Pages (from-to)854-858
Number of pages5
JournalFertility and sterility
Volume63
Issue number4
DOIs
StatePublished - Jan 1 1995

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All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

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