Animal, but not human, faces engage the distributed face network in adolescents with autism

Elisabeth M. Whyte, Marlene Behrmann, Nancy J. Minshew, Natalie V. Garcia, K. Suzanne Scherf

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Multiple hypotheses have been offered to explain the impaired face-processing behavior and the accompanying underlying disruptions in neural circuitry among individuals with autism. We explored the specificity of atypical face-processing activation and potential alterations to fusiform gyrus (FG) morphology as potential underlying mechanisms. Adolescents with high functioning autism (HFA) and age-matched typically developing (TD) adolescents were scanned with sMRI and fMRI as they observed human and animal faces. In spite of exhibiting comparable face recognition behavior, the HFA adolescents evinced hypo-activation throughout the face-processing system in response to unfamiliar human, but not animal, faces. They also exhibited greater activation in affective regions of the face-processing network in response to animal, but not human, faces. Importantly, this atypical pattern of activation in response to human faces was not related to atypical structural properties of the FG. This atypical neural response to human faces in autism may stem from abnormalities in the ability to represent the reward value of social (i.e. conspecific) stimuli.

Original languageEnglish (US)
Pages (from-to)306-317
Number of pages12
JournalDevelopmental Science
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2016

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Animal, but not human, faces engage the distributed face network in adolescents with autism'. Together they form a unique fingerprint.

  • Cite this