Anisotropic conductivity tensor for irreversible electroporation simulations

Nicholas LaBarbera, Corina Drapaca

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.

Original languageEnglish (US)
Title of host publicationMechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics
EditorsMartha Grady, Wendy Crone, Pablo Zavattieri, Kathryn Dannemann, Majid Minary
PublisherSpringer New York LLC
Pages29-35
Number of pages7
ISBN (Print)9783319635514
DOIs
StatePublished - Jan 1 2018
EventAnnual Conference and Exposition on Experimental and Applied Mechanics, 2017 - Indianapolis, United States
Duration: Jun 12 2017Jun 15 2017

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
Volume4
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652

Other

OtherAnnual Conference and Exposition on Experimental and Applied Mechanics, 2017
CountryUnited States
CityIndianapolis
Period6/12/176/15/17

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All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Computational Mechanics
  • Mechanical Engineering

Cite this

LaBarbera, N., & Drapaca, C. (2018). Anisotropic conductivity tensor for irreversible electroporation simulations. In M. Grady, W. Crone, P. Zavattieri, K. Dannemann, & M. Minary (Eds.), Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics (pp. 29-35). (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4). Springer New York LLC. https://doi.org/10.1007/978-3-319-63552-1_5