Abstract
In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.
| Original language | English (US) |
|---|---|
| Title of host publication | Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics |
| Editors | Martha Grady, Wendy Crone, Pablo Zavattieri, Kathryn Dannemann, Majid Minary |
| Publisher | Springer New York LLC |
| Pages | 29-35 |
| Number of pages | 7 |
| ISBN (Print) | 9783319635514 |
| DOIs | |
| State | Published - Jan 1 2018 |
| Event | Annual Conference and Exposition on Experimental and Applied Mechanics, 2017 - Indianapolis, United States Duration: Jun 12 2017 → Jun 15 2017 |
Publication series
| Name | Conference Proceedings of the Society for Experimental Mechanics Series |
|---|---|
| Volume | 4 |
| ISSN (Print) | 2191-5644 |
| ISSN (Electronic) | 2191-5652 |
Other
| Other | Annual Conference and Exposition on Experimental and Applied Mechanics, 2017 |
|---|---|
| Country | United States |
| City | Indianapolis |
| Period | 6/12/17 → 6/15/17 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
- Computational Mechanics
- Mechanical Engineering
Cite this
}
Anisotropic conductivity tensor for irreversible electroporation simulations. / LaBarbera, Nicholas; Drapaca, Corina Stefania.
Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. ed. / Martha Grady; Wendy Crone; Pablo Zavattieri; Kathryn Dannemann; Majid Minary. Springer New York LLC, 2018. p. 29-35 (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Anisotropic conductivity tensor for irreversible electroporation simulations
AU - LaBarbera, Nicholas
AU - Drapaca, Corina Stefania
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.
AB - In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.
UR - http://www.scopus.com/inward/record.url?scp=85032470373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032470373&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-63552-1_5
DO - 10.1007/978-3-319-63552-1_5
M3 - Conference contribution
AN - SCOPUS:85032470373
SN - 9783319635514
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 29
EP - 35
BT - Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics
A2 - Grady, Martha
A2 - Crone, Wendy
A2 - Zavattieri, Pablo
A2 - Dannemann, Kathryn
A2 - Minary, Majid
PB - Springer New York LLC
ER -