Aspects of wave mechanics in inhomogeneous and anisotropic media are presented in the paper that relate to potential speckle pattern variations in B-scan imaging analysis. The hypothesis is explored that diseased or malignancy areas embedded inside larger tissue masses become more or less anisotropic or ordered or disordered compared to the surrounding tissue. It is shown that speckle pattern variations due to impingement angle or scan direction can occur that relates to the anisotropic or ordered character of the tissue. This often neglected impingement angle feature can potentially be used to solve many different problems in tissue characterization. The influence of frequency and frequency bandwidth is also studied with respect to image quality and characterization potential. Sample problems are presented in phantom analysis of unidirectional fibers in a fluid media in an attempt to direct the technological efforts towards in-vivo tissue characterization analysis.