Anomalous gray matter structural networks in recent onset post-traumatic stress disorder

Shun Qi, Yun Feng Mu, Long Biao Cui, Jian Zhang, Fan Guo, Qing Rong Tan, Mei Shi, Kang Liu, Yi Bin Xi, Nan Yin Zhang, Xiao Liang Zhang, Yong He, Jian Yang, Hong Yin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.

Original languageEnglish (US)
Pages (from-to)390-401
Number of pages12
JournalBrain Imaging and Behavior
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Post-Traumatic Stress Disorders
Occipital Lobe
Prefrontal Cortex
Parahippocampal Gyrus
Gyrus Cinguli
Parietal Lobe
Disasters
Temporal Lobe
Gray Matter
Fear
Cluster Analysis
Pathology
Brain

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Qi, Shun ; Mu, Yun Feng ; Cui, Long Biao ; Zhang, Jian ; Guo, Fan ; Tan, Qing Rong ; Shi, Mei ; Liu, Kang ; Xi, Yi Bin ; Zhang, Nan Yin ; Zhang, Xiao Liang ; He, Yong ; Yang, Jian ; Yin, Hong. / Anomalous gray matter structural networks in recent onset post-traumatic stress disorder. In: Brain Imaging and Behavior. 2018 ; Vol. 12, No. 2. pp. 390-401.
@article{26a1a87e9462463abeae6063e501dd06,
title = "Anomalous gray matter structural networks in recent onset post-traumatic stress disorder",
abstract = "Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.",
author = "Shun Qi and Mu, {Yun Feng} and Cui, {Long Biao} and Jian Zhang and Fan Guo and Tan, {Qing Rong} and Mei Shi and Kang Liu and Xi, {Yi Bin} and Zhang, {Nan Yin} and Zhang, {Xiao Liang} and Yong He and Jian Yang and Hong Yin",
year = "2018",
month = "4",
day = "1",
doi = "10.1007/s11682-017-9693-z",
language = "English (US)",
volume = "12",
pages = "390--401",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "2",

}

Qi, S, Mu, YF, Cui, LB, Zhang, J, Guo, F, Tan, QR, Shi, M, Liu, K, Xi, YB, Zhang, NY, Zhang, XL, He, Y, Yang, J & Yin, H 2018, 'Anomalous gray matter structural networks in recent onset post-traumatic stress disorder', Brain Imaging and Behavior, vol. 12, no. 2, pp. 390-401. https://doi.org/10.1007/s11682-017-9693-z

Anomalous gray matter structural networks in recent onset post-traumatic stress disorder. / Qi, Shun; Mu, Yun Feng; Cui, Long Biao; Zhang, Jian; Guo, Fan; Tan, Qing Rong; Shi, Mei; Liu, Kang; Xi, Yi Bin; Zhang, Nan Yin; Zhang, Xiao Liang; He, Yong; Yang, Jian; Yin, Hong.

In: Brain Imaging and Behavior, Vol. 12, No. 2, 01.04.2018, p. 390-401.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anomalous gray matter structural networks in recent onset post-traumatic stress disorder

AU - Qi, Shun

AU - Mu, Yun Feng

AU - Cui, Long Biao

AU - Zhang, Jian

AU - Guo, Fan

AU - Tan, Qing Rong

AU - Shi, Mei

AU - Liu, Kang

AU - Xi, Yi Bin

AU - Zhang, Nan Yin

AU - Zhang, Xiao Liang

AU - He, Yong

AU - Yang, Jian

AU - Yin, Hong

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.

AB - Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.

UR - http://www.scopus.com/inward/record.url?scp=85015157849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015157849&partnerID=8YFLogxK

U2 - 10.1007/s11682-017-9693-z

DO - 10.1007/s11682-017-9693-z

M3 - Article

C2 - 28293804

AN - SCOPUS:85015157849

VL - 12

SP - 390

EP - 401

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 2

ER -