Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions

Marco Brustolin, Sujit Pujhari, Cory A. Henderson, Jason Laurence Rasgon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Togavirus (Alphavirus) Mayaro virus (MAYV) was initially described in 1954 from Mayaro County (Trinidad) and has been responsible for outbreaks in South America and the Caribbean. Imported MAYV cases are on the rise, leading to invasion concerns similar to Chikungunya and Zika viruses. Little is known about the range of mosquito species that are competent MAYV vectors. We tested vector competence of 2 MAYV genotypes in laboratory strains of six mosquito species (Aedes aegypti, Anopheles freeborni, An. gambiae, An. quadrimaculatus, An. stephensi, Culex quinquefasciatus). Ae. aegypti and Cx. quinquefasciatus were poor MAYV vectors, and had either poor or null infection and transmission rates at the tested viral challenge titers. In contrast, all Anopheles species were able to transmit MAYV, and 3 of the 4 species transmitted both genotypes. The Anopheles species tested are divergent and native to widely separated geographic regions (Africa, Asia, North America), suggesting that Anopheles may be important in the invasion and spread of MAYV across diverse regions of the world.

Original languageEnglish (US)
Article numbere0006895
JournalPLoS neglected tropical diseases
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2018

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Anopheles
Culicidae
Viruses
Togaviridae
Genotype
Chikungunya virus
Trinidad and Tobago
Alphavirus
Culex
Infectious Disease Transmission
South America
Aedes
North America
Drive
Mental Competency
Disease Outbreaks

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

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title = "Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions",
abstract = "The Togavirus (Alphavirus) Mayaro virus (MAYV) was initially described in 1954 from Mayaro County (Trinidad) and has been responsible for outbreaks in South America and the Caribbean. Imported MAYV cases are on the rise, leading to invasion concerns similar to Chikungunya and Zika viruses. Little is known about the range of mosquito species that are competent MAYV vectors. We tested vector competence of 2 MAYV genotypes in laboratory strains of six mosquito species (Aedes aegypti, Anopheles freeborni, An. gambiae, An. quadrimaculatus, An. stephensi, Culex quinquefasciatus). Ae. aegypti and Cx. quinquefasciatus were poor MAYV vectors, and had either poor or null infection and transmission rates at the tested viral challenge titers. In contrast, all Anopheles species were able to transmit MAYV, and 3 of the 4 species transmitted both genotypes. The Anopheles species tested are divergent and native to widely separated geographic regions (Africa, Asia, North America), suggesting that Anopheles may be important in the invasion and spread of MAYV across diverse regions of the world.",
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Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions. / Brustolin, Marco; Pujhari, Sujit; Henderson, Cory A.; Rasgon, Jason Laurence.

In: PLoS neglected tropical diseases, Vol. 12, No. 11, e0006895, 01.11.2018.

Research output: Contribution to journalArticle

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