Anorectic specificity as measured in a choice paradigm in rhesus monkeys

Rebecca L. Corwin, Charles R. Schuster

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7 Scopus citations

Abstract

The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric cathetets were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalPharmacology, Biochemistry and Behavior
Volume45
Issue number1
DOIs
StatePublished - May 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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