Anterior cruciate ligament allograft transplantation in dogs

P. B. Vasseur, S. Stevenson, C. R. Gregory, J. J. Rodrigo, S. Pauli, D. Heitter, Neil Sharkey

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The biomechanical and clinical performance of bone-ligament-bone anterior cruciate ligament (ACL) allografts was studied in eight dogs. Allografts were collected from skeletally mature, healthy dogs using aseptic technique, and stored at -70° for three to five weeks before implantation. The allografts were size-matched to the recipient dogs using ACL length and then rigidly fixed in position with interference screws and Kirschner wires. Three dogs regained a normal gait, and their grafts sustained breaking loads that were 25%, 41%, and 59% of controls. Partial or complete graft failure occurred in the other five dogs at some point in the study. Four had intraligamentous rupture and one had an avulsion fracture of the femoral attachment site. Joint-fluid cytology was normal in all eight dogs. Histologic examination showed persistent lymphoplasmacytic infiltrate. Eventually the allograft cores were incorporated in the host bed. Hyperplasia and fibrosis of the synovial membrane were diffuse and persisted as focal accumulations of mononuclear inflammatory cells.

Original languageEnglish (US)
Pages (from-to)295-304
Number of pages10
JournalClinical Orthopaedics and Related Research
Issue number269
StatePublished - Dec 1 1991

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Anterior Cruciate Ligament
Allografts
Transplantation
Dogs
Bone Wires
Transplants
Synovial Membrane
Thigh
Gait
Ligaments
Hyperplasia
Cell Biology
Rupture
Fibrosis
Joints
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Vasseur, P. B., Stevenson, S., Gregory, C. R., Rodrigo, J. J., Pauli, S., Heitter, D., & Sharkey, N. (1991). Anterior cruciate ligament allograft transplantation in dogs. Clinical Orthopaedics and Related Research, (269), 295-304.
Vasseur, P. B. ; Stevenson, S. ; Gregory, C. R. ; Rodrigo, J. J. ; Pauli, S. ; Heitter, D. ; Sharkey, Neil. / Anterior cruciate ligament allograft transplantation in dogs. In: Clinical Orthopaedics and Related Research. 1991 ; No. 269. pp. 295-304.
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Vasseur, PB, Stevenson, S, Gregory, CR, Rodrigo, JJ, Pauli, S, Heitter, D & Sharkey, N 1991, 'Anterior cruciate ligament allograft transplantation in dogs', Clinical Orthopaedics and Related Research, no. 269, pp. 295-304.

Anterior cruciate ligament allograft transplantation in dogs. / Vasseur, P. B.; Stevenson, S.; Gregory, C. R.; Rodrigo, J. J.; Pauli, S.; Heitter, D.; Sharkey, Neil.

In: Clinical Orthopaedics and Related Research, No. 269, 01.12.1991, p. 295-304.

Research output: Contribution to journalArticle

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Vasseur PB, Stevenson S, Gregory CR, Rodrigo JJ, Pauli S, Heitter D et al. Anterior cruciate ligament allograft transplantation in dogs. Clinical Orthopaedics and Related Research. 1991 Dec 1;(269):295-304.